Publication: Interactions of Human- and Rat-Organic Anion Transporters with Pravastatin and Cimetidine
Issued Date
2004-02-01
Resource Type
ISSN
13478613
Other identifier(s)
2-s2.0-1642422265
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Pharmacological Sciences. Vol.94, No.2 (2004), 197-202
Suggested Citation
Suparat Khamdang, Michio Takeda, Minoru Shimoda, Rie Noshiro, Shinichi Narikawa, Xiu Lin Huang, Atsushi Enomoto, Pawinee Piyachaturawat, Hitoshi Endou Interactions of Human- and Rat-Organic Anion Transporters with Pravastatin and Cimetidine. Journal of Pharmacological Sciences. Vol.94, No.2 (2004), 197-202. doi:10.1254/jphs.94.197 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21807
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Title
Interactions of Human- and Rat-Organic Anion Transporters with Pravastatin and Cimetidine
Abstract
We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOAT3 and hOAT4. Cimetidine also inhibited hOAT1/rOAT1, hOAT3/rOAT3, and hOAT4. The mode of inhibition was a combination of competitive and noncompetitive manners for hOAT1, whereas it was competitive for hOAT3. The effects of OAT inhibitors on OAT1, OAT2, and OAT3 exhibited some but not so remarkable interspecies differences between humans and rats. In conclusion, we have characterized pravastatin and cimetidine as OAT inhibitors.