Publication: Plant anticancer agents, l. cytotoxic triterpenes from sandoricum koetjape stems
No. of Pages/File Size
Journal of Natural Products. Vol.55, No.5 (1992), 654-659
Norito Kaneda, John M. Pezzuto, Douglas Kinghorn, Norman R. Farnsworth, Thawatchai Santisuk, Patoomratana Tuchinda, Jinda Udchachon, Vichai Reutrakul (1992). Plant anticancer agents, l. cytotoxic triterpenes from sandoricum koetjape stems. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/22256.
Plant anticancer agents, l. cytotoxic triterpenes from sandoricum koetjape stems
A new ring-A secotriterpene, koetjapic acid , and five known compounds, 3-oxo-olean-12-en-29-oic acid  (a novel natural product), katonic acid , (−)-alloaromadendrene, (−)-caryophyllene oxide, and (+)-spathulenol, have been isolated and characterized from a cytotoxic Et2O-soluble extract of Sandoricum koetjape stems. Of these compounds, 2 and 3 demonstrated significant cytotoxic activity against cultured P-388 cells (ED50values of 0.61 and 0.11 μg/ml, respectively). Significant, albeit less intense, cytotoxicity was also observed with a variety of cultured human cancer cells. The13C-nmr chemical shifts of these triterpenes were assigned unambiguously using selective INEPT nmr experiments. Aside from compounds 2 and 3, these substances were not toxic with cultured cells. © 1992, American Chemical Society. All rights reserved.