Publication: Cytochalasin E: Inhibition of intestinal glucose absorption in the mouse
Issued Date
1983-01-01
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ISSN
03784274
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2-s2.0-0020692484
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Mahidol University
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SCOPUS
Bibliographic Citation
Toxicology Letters. Vol.15, No.4 (1983), 341-348
Suggested Citation
T. Glinsukon, B. Kongsuktrakoon, C. Toskulkao, S. Sophasan Cytochalasin E: Inhibition of intestinal glucose absorption in the mouse. Toxicology Letters. Vol.15, No.4 (1983), 341-348. doi:10.1016/0378-4274(83)90154-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30548
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Title
Cytochalasin E: Inhibition of intestinal glucose absorption in the mouse
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Abstract
In situ glucose absorption in the mouse was significantly inhibited by cytochalasin E. Cytochalasin E (5 mg/ml) also inhibited glucose absorption up to 55.5% in mouse jejunum in vitro. During its inhibition transmural potential difference (PD) was increased from -7.4 to -0.4 mV, together with a decrease in glucose accumulation in the intestinal tissues. Furthermore, it was also found that cytochalasin E induced an alteration in Kmvalue from 2.9 · 10-3to 4.0 · 10-2M and a constant Vmaxvalue of 55.5 smmol/100 mg wet wt tissue/min. It is postulated that cytochalasin E is a possible competitive inhibitor of glucose at the receptor sites of carriers on the microvillar membrane of the intestinal absorptive cells. © 1983.