Publication: Molecular investigation of carbapenem resistance among multidrug-resistant Pseudomonas aeruginosa isolated clinically in Thailand
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Issued Date
2013-03-01
Resource Type
ISSN
13480421
03855600
03855600
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2-s2.0-84875243491
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Mahidol University
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SCOPUS
Bibliographic Citation
Microbiology and Immunology. Vol.57, No.3 (2013), 170-178
Suggested Citation
Piyatip Khuntayaporn, Preecha Montakantikul, Pitak Santanirand, Pattarachai Kiratisin, Mullika Traidej Chomnawang Molecular investigation of carbapenem resistance among multidrug-resistant Pseudomonas aeruginosa isolated clinically in Thailand. Microbiology and Immunology. Vol.57, No.3 (2013), 170-178. doi:10.1111/1348-0421.12021 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31953
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Title
Molecular investigation of carbapenem resistance among multidrug-resistant Pseudomonas aeruginosa isolated clinically in Thailand
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Abstract
Carbapenem resistant Pseudomonas aeruginosa were isolated among multidrug-resistant (CR-MDR) organisms from tertiary hospitals in Thailand. Decreased expression of oprD mRNA (93.65%) was predominant followed by increased expression of mexAB-oprM mRNA (92.06%) and mexXY mRNA (63.49%). Interestingly, 23 of 126 (18.25%) isolates were susceptible to imipenem with down-regulated oprD expression and non-up-regulated mexCD-oprJ mRNA expression. Metallo-β-lactamases production was clearly positive in 24 isolates (18.46%) and weakly positive in 12 isolates (9.23%). Among both of these sets of isolates, imp-1, imp-14 and vim-2 were identified. Hyperproduction of AmpC β-lactamase had the lowest prevalence rate (3.97%). It was concluded that CR-MDR P. aeruginosa clinical isolates in Thailand possess multifactorial resistance mechanisms. © 2012 The Societies and Wiley Publishing Asia Pty Ltd.