Publication:
Monte carlo cellular automata simulation of receptor trafficking in cell signal transduction: Tracking dimer and oligomer formation

2

Issued Date

2015-11-15

Resource Type

Article

ISSN

00755192

Other identifier(s)

2-s2.0-84988810653

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Kasetsart Journal - Natural Science. Vol.49, No.6 (2015), 1036-1046

Suggested Citation

Chontita Rattanakul, Yongwimon Lenbury Monte carlo cellular automata simulation of receptor trafficking in cell signal transduction: Tracking dimer and oligomer formation. Kasetsart Journal - Natural Science. Vol.49, No.6 (2015), 1036-1046. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35071

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Title

Monte carlo cellular automata simulation of receptor trafficking in cell signal transduction: Tracking dimer and oligomer formation

Author(s)

Chontita Rattanakul
 Yongwimon Lenbury

Other Contributor(s)

Mahidol University
 South Carolina Commission on Higher Education

Abstract

© 2015, Kasetsart University. All rights reserved. A cellular automata (CA) model of the signal transduction pathway mediated by calcium sensing (CaS) receptors was constructed to investigate the effects of different fractions of healthy (functional) and defective receptors. Receptor trafficking was allowed to take place leading to dimerization and oligomerization which exerted a positive impact on the receptor binding affinity. Snapshots of receptor trafficking and distribution over the cell membrane simulated by the CA model were compared with the no-trafficking case.

Keyword(s)

Agricultural and Biological Sciences

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/35071

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Scopus 2011-2015