Publication: Plasmodium falciparum genetic crosses in a humanized mouse model
Issued Date
2015-06-30
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ISSN
15487105
15487091
15487091
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2-s2.0-84934442316
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Methods. Vol.12, No.7 (2015), 631-633
Suggested Citation
Ashley M. Vaughan, Richard S. Pinapati, Ian H. Cheeseman, Nelly Camargo, Matthew Fishbaugher, Lisa A. Checkley, Shalini Nair, Carolyn A. Hutyra, François H. Nosten, Timothy J.C. Anderson, Michael T. Ferdig, Stefan H.I. Kappe Plasmodium falciparum genetic crosses in a humanized mouse model. Nature Methods. Vol.12, No.7 (2015), 631-633. doi:10.1038/nmeth.3432 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35432
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Title
Plasmodium falciparum genetic crosses in a humanized mouse model
Abstract
© 2015 Nature America, Inc. All rights reserved. Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.