Publication: Insights into drug resistance mechanisms in Clostridium difficile
1
Issued Date
2017-03-03
Resource Type
ISSN
00711365
Other identifier(s)
2-s2.0-85015456660
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Essays in Biochemistry. Vol.61, No.1 (2017), 81-88
Suggested Citation
Phurt Harnvoravongchai, Methinee Pipatthana, Surang Chankhamhaengdecha, Tavan Janvilisri Insights into drug resistance mechanisms in Clostridium difficile. Essays in Biochemistry. Vol.61, No.1 (2017), 81-88. doi:10.1042/EBC20160062 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/41951
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Insights into drug resistance mechanisms in Clostridium difficile
Other Contributor(s)
Abstract
© 2017 The Author(s). The incidence of Clostridium difficile infection has been elevated and becoming common in hospitals worldwide. Although antibiotics usually serve as the primary treatment for bacterial infection including C. difficile infection, limitations and failures have been evident due to drug resistance. Antibiotic resistance in C. difficile has been recognized as one of the most important factors to promote the infection and increase the level of severity and the recurrence rate. Several outbreaks in many countries have been linked to the emergence of hypervirulent drug-resistant strains. This pathogen harbours various mechanisms against the actions of antibiotics. The present study highlights three main drug-resistant strategies in C. difficile including drug inactivation, target modification and efflux pump. Other mechanisms that potentially contribute to drug-resistant traits in this organism are also discussed.