Publication:
Correlation of Vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects

1

Issued Date

2018-09-01

Resource Type

Article

ISSN

1744828X
17410541

DOI

10.2217/pme-2018-0005

Other identifier(s)

2-s2.0-85054626575

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Personalized Medicine. Vol.15, No.5 (2018), 371-379

Suggested Citation

Benjamas Chuaychoo, Rungsunn Tungtrongchitr, Wantanee Kriengsinyos, Siriporn Tuntipopipat, Nattira On-Nom, Chaowanee Chupeerach Correlation of Vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects. Personalized Medicine. Vol.15, No.5 (2018), 371-379. doi:10.2217/pme-2018-0005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45055

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Title

Correlation of Vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects

Author(s)

Benjamas Chuaychoo
 Rungsunn Tungtrongchitr
 Wantanee Kriengsinyos
 Siriporn Tuntipopipat
 Nattira On-Nom
 Chaowanee Chupeerach

Other Contributor(s)

Mahidol University
 Faculty of Medicine, Siriraj Hospital, Mahidol University

Abstract

© 2018 Future Medicine Ltd. Aim: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated. Materials & methods: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males. Results: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference. Significantly lower average DBP serum levels were observed in COPD than non-COPD subjects. Positive correlation between serum DBP and forced expiratory volume at 1 s % predicted was observed in non-COPD subjects. Discussion & conclusion: DBP variations might be associated with risk factors in COPD caused by both inflammatory and vitamin D circulation processes.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/45055

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