Publication: Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion
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2019-01-23
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14752875
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2-s2.0-85060396457
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Mahidol University
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Malaria Journal. Vol.18, No.1 (2019)
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Germana Bancone, Didier Menard, Nimol Khim, Saorin Kim, Lydie Canier, Chea Nguong, Koukeo Phommasone, Mayfong Mayxay, Sabine Dittrich, Malavanh Vongsouvath, Nadine Fievet, Jean Yves Le Hesran, Valerie Briand, Sommay Keomany, Paul N. Newton, Gornpan Gorsawun, Kaelan Tardy, Cindy S. Chu, Orpreeya Rattanapalroj, Le Thanh Dong, Huynh Hong Quang, Nguyen Tam-Uyen, Nguyen Thuy-Nhien, Tran Tinh Hien, Michael Kalnoky, Francois Nosten (2019). Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/51111.
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Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion
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Germana Bancone
Didier Menard
Nimol Khim
Saorin Kim
Lydie Canier
Chea Nguong
Koukeo Phommasone
Mayfong Mayxay
Sabine Dittrich
Malavanh Vongsouvath
Nadine Fievet
Jean Yves Le Hesran
Valerie Briand
Sommay Keomany
Paul N. Newton
Gornpan Gorsawun
Kaelan Tardy
Cindy S. Chu
Orpreeya Rattanapalroj
Le Thanh Dong
Huynh Hong Quang
Nguyen Tam-Uyen
Nguyen Thuy-Nhien
Tran Tinh Hien
Michael Kalnoky
Francois Nosten
Didier Menard
Nimol Khim
Saorin Kim
Lydie Canier
Chea Nguong
Koukeo Phommasone
Mayfong Mayxay
Sabine Dittrich
Malavanh Vongsouvath
Nadine Fievet
Jean Yves Le Hesran
Valerie Briand
Sommay Keomany
Paul N. Newton
Gornpan Gorsawun
Kaelan Tardy
Cindy S. Chu
Orpreeya Rattanapalroj
Le Thanh Dong
Huynh Hong Quang
Nguyen Tam-Uyen
Nguyen Thuy-Nhien
Tran Tinh Hien
Michael Kalnoky
Francois Nosten
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Foundation for Innovative New Diagnostics, Switzerland
Institut Pasteur du Cambodge
Universite Paris Descartes
UCL
Mahidol University
Nuffield Department of Clinical Medicine
Institut Pasteur, Paris
Institute of Malariology Parasitology and Entomology - Quy Nhon (IMPE-QN)
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)
Bureau of Vector Borne Diseases
Institute of Malariology-Parasitology and Entomology (IMPE)
National Center for Parasitology, Entomology and Malaria Control (CNM)
PATH
Salavan Provincial Hospital
University of Health Sciences
Institut Pasteur du Cambodge
Universite Paris Descartes
UCL
Mahidol University
Nuffield Department of Clinical Medicine
Institut Pasteur, Paris
Institute of Malariology Parasitology and Entomology - Quy Nhon (IMPE-QN)
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)
Bureau of Vector Borne Diseases
Institute of Malariology-Parasitology and Entomology (IMPE)
National Center for Parasitology, Entomology and Malaria Control (CNM)
PATH
Salavan Provincial Hospital
University of Health Sciences
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Abstract
© 2019 The Author(s). Background: Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam. Methods: Blood samples were collected in the five countries during National Malaria Surveys or during Population Surveys. During Population Surveys samples were characterized for G6PD phenotype using the Fluorescent Spot Test. Samples were then genotyped for a panel of G6PD mutations. Results: G6PD deficiency was found to be common in the region with an overall mean prevalence of deficient or mutated hemizygous males of 14.0%, ranging from a mean 7.3% in Thailand, 8.1% in Lao PDR, 8.9% in Vietnam, 15.8% in Myanmar and 18.8% in Cambodia. Mahidol and Viangchan mutations were the most common and widespread variants found among the nine investigated. Conclusions: Owing to the high prevalence of G6PD deficiency in the Greater Mekong Subregion, strategies for vivax malaria elimination should include point-of-care G6PD testing (both qualitative and quantitative) to allow safe and wide treatment with 8-aminoquinolines.