Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
1
Issued Date
2022-12-01
Resource Type
eISSN
20411723
Scopus ID
2-s2.0-85143185703
Pubmed ID
36456547
Journal Title
Nature Communications
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications Vol.13 No.1 (2022)
Suggested Citation
Munk P., Brinch C., Møller F.D., Petersen T.N., Hendriksen R.S., Seyfarth A.M., Kjeldgaard J.S., Svendsen C.A., van Bunnik B., Berglund F., Bego A., Power P., Rees C., Lambrinidis D., Neilson E.H.J., Gibb K., Coventry K., Collignon P., Cassar S., Allerberger F., Begum A., Hossain Z.Z., Worrell C., Vandenberg O., Pieters I., Victorien D.T., Gutierrez A.D.S., Soria F., Grujić V.R., Mazalica N., Rahube T.O., Tagliati C.A., Rodrigues D., Oliveira G., de Souza L.C.R., Ivanov I., Juste B.I., Oumar T., Sopheak T., Vuthy Y., Ngandijo A., Nzouankeu A., Olivier Z.A.A.J., Yost C.K., Kumar P., Brar S.K., Tabo D.A., Adell A.D., Paredes-Osses E., Martinez M.C., Sara C.O., Ke C., Zheng H., Baisheng L., Lau L.T., Chung T., Jiao X., Yu Y., JiaYong Z., Morales J.F.B., Valencia M.F., Donado-Godoy P., Coulibaly K.J., Hrenovic J., Jergović M., Karpíšková R., Deogratias Z.N., Elsborg B., Hansen L.T., Jensen P.E., Abouelnaga M., Salem M.F., Koolmeister M., Legesse M., Eguale T., Heikinheimo A., Le Guyader S., Schaeffer J., Villacis J.E., Sanneh B., Malania L., Nitsche A., Brinkmann A., Schubert S., Hesse S., Berendonk T.U., Saba C.K.S., Mohammed J., Feglo P.K., Banu R.A., Kotzamanidis C., Lytras E., Lickes S.A., Kocsis B., Solymosi N., Thorsteinsdottir T.R., Hatha A.M., Ballal M., Bangera S.R., Fani F. Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. Nature Communications Vol.13 No.1 (2022). doi:10.1038/s41467-022-34312-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/86905
Title
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Author(s)
Munk P.
Brinch C.
Møller F.D.
Petersen T.N.
Hendriksen R.S.
Seyfarth A.M.
Kjeldgaard J.S.
Svendsen C.A.
van Bunnik B.
Berglund F.
Bego A.
Power P.
Rees C.
Lambrinidis D.
Neilson E.H.J.
Gibb K.
Coventry K.
Collignon P.
Cassar S.
Allerberger F.
Begum A.
Hossain Z.Z.
Worrell C.
Vandenberg O.
Pieters I.
Victorien D.T.
Gutierrez A.D.S.
Soria F.
Grujić V.R.
Mazalica N.
Rahube T.O.
Tagliati C.A.
Rodrigues D.
Oliveira G.
de Souza L.C.R.
Ivanov I.
Juste B.I.
Oumar T.
Sopheak T.
Vuthy Y.
Ngandijo A.
Nzouankeu A.
Olivier Z.A.A.J.
Yost C.K.
Kumar P.
Brar S.K.
Tabo D.A.
Adell A.D.
Paredes-Osses E.
Martinez M.C.
Sara C.O.
Ke C.
Zheng H.
Baisheng L.
Lau L.T.
Chung T.
Jiao X.
Yu Y.
JiaYong Z.
Morales J.F.B.
Valencia M.F.
Donado-Godoy P.
Coulibaly K.J.
Hrenovic J.
Jergović M.
Karpíšková R.
Deogratias Z.N.
Elsborg B.
Hansen L.T.
Jensen P.E.
Abouelnaga M.
Salem M.F.
Koolmeister M.
Legesse M.
Eguale T.
Heikinheimo A.
Le Guyader S.
Schaeffer J.
Villacis J.E.
Sanneh B.
Malania L.
Nitsche A.
Brinkmann A.
Schubert S.
Hesse S.
Berendonk T.U.
Saba C.K.S.
Mohammed J.
Feglo P.K.
Banu R.A.
Kotzamanidis C.
Lytras E.
Lickes S.A.
Kocsis B.
Solymosi N.
Thorsteinsdottir T.R.
Hatha A.M.
Ballal M.
Bangera S.R.
Fani F.
Brinch C.
Møller F.D.
Petersen T.N.
Hendriksen R.S.
Seyfarth A.M.
Kjeldgaard J.S.
Svendsen C.A.
van Bunnik B.
Berglund F.
Bego A.
Power P.
Rees C.
Lambrinidis D.
Neilson E.H.J.
Gibb K.
Coventry K.
Collignon P.
Cassar S.
Allerberger F.
Begum A.
Hossain Z.Z.
Worrell C.
Vandenberg O.
Pieters I.
Victorien D.T.
Gutierrez A.D.S.
Soria F.
Grujić V.R.
Mazalica N.
Rahube T.O.
Tagliati C.A.
Rodrigues D.
Oliveira G.
de Souza L.C.R.
Ivanov I.
Juste B.I.
Oumar T.
Sopheak T.
Vuthy Y.
Ngandijo A.
Nzouankeu A.
Olivier Z.A.A.J.
Yost C.K.
Kumar P.
Brar S.K.
Tabo D.A.
Adell A.D.
Paredes-Osses E.
Martinez M.C.
Sara C.O.
Ke C.
Zheng H.
Baisheng L.
Lau L.T.
Chung T.
Jiao X.
Yu Y.
JiaYong Z.
Morales J.F.B.
Valencia M.F.
Donado-Godoy P.
Coulibaly K.J.
Hrenovic J.
Jergović M.
Karpíšková R.
Deogratias Z.N.
Elsborg B.
Hansen L.T.
Jensen P.E.
Abouelnaga M.
Salem M.F.
Koolmeister M.
Legesse M.
Eguale T.
Heikinheimo A.
Le Guyader S.
Schaeffer J.
Villacis J.E.
Sanneh B.
Malania L.
Nitsche A.
Brinkmann A.
Schubert S.
Hesse S.
Berendonk T.U.
Saba C.K.S.
Mohammed J.
Feglo P.K.
Banu R.A.
Kotzamanidis C.
Lytras E.
Lickes S.A.
Kocsis B.
Solymosi N.
Thorsteinsdottir T.R.
Hatha A.M.
Ballal M.
Bangera S.R.
Fani F.
Author's Affiliation
Instituto Tecnológico Vale
University of Sadat City
Botswana International University of Science and Technology
University of Banja Luka
Melbourne Water Corporation
Guangdong Center for Disease Control and Prevention
Universite de N'Djamena
Universidad de San Carlos de Guatemala
Institute of Public Health Albania
University of Ouagadougou
Institut Pasteur du Cambodge
Institut Pasteur de Cote-d'Ivoire
University for Development Studies Ghana
Kwame Nkrumah University of Science and Technology
CSIR - Water Research Institute Ghana
Addis Ababa University
Haskoli Islands
Institut National de la Recherche Scientifique
Centre Pasteur du Cameroun
Aquafin, Belgium
Nanjing University of Information Science & Technology
Cochin University of Science and Technology
Chinese Center for Disease Control and Prevention
Københavns Universitet
University of Regina
Universidade Federal de Minas Gerais
Veterinary Research Institute, Brno
Hellenic Agricultural Organization-DIMITRAADA
National Center of Infectious and Parasitic Diseases Bulgaria
The University of Edinburgh
Általános Orvostudományi Kar
Fundacao Oswaldo Cruz
Shiraz University of Medical Sciences
Suez Canal University
IFREMER Institut Francais de Recherche pour l'Exploitation de la Mer
Technische Universität Dresden
University of Ghana
Canberra Hospital
Göteborgs Universitet
Robert Koch Institut
Kasturba Medical College, Manipal
University of Dhaka
Technical University of Denmark
Shantou University Medical College
Instituto de Salud Publica de Chile
Universidad Católica del Maule
Hong Kong Polytechnic University
University of Zagreb
University of Zagreb School of Medicine
University of Veterinary Medicine Budapest
Charles Darwin University
Austrian Agency for Health and Food Safety
Helsingin Yliopisto
Universidad Andrés Bello
Universidad de Buenos Aires
CI Tibaitatα
Apollo Diagnostics
Galαpagos
Universidad Catσlica Boliviana San Pablo
Polytechnic School of Abomey-Calavi (EPAC)
Laboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB)
Ministry of Health and Social Welfare
National Center for Disease Control and Public Health
ALS Water
BIOFOS A/S
Centre de Recherche en Sciences Naturelles (CRSN)
Ministry of Health
Public Health Institute of Republic of Srpska
Bridgetown
Athens Water Supply and Sewerage Company (EYDAP SA)
University of Sadat City
Botswana International University of Science and Technology
University of Banja Luka
Melbourne Water Corporation
Guangdong Center for Disease Control and Prevention
Universite de N'Djamena
Universidad de San Carlos de Guatemala
Institute of Public Health Albania
University of Ouagadougou
Institut Pasteur du Cambodge
Institut Pasteur de Cote-d'Ivoire
University for Development Studies Ghana
Kwame Nkrumah University of Science and Technology
CSIR - Water Research Institute Ghana
Addis Ababa University
Haskoli Islands
Institut National de la Recherche Scientifique
Centre Pasteur du Cameroun
Aquafin, Belgium
Nanjing University of Information Science & Technology
Cochin University of Science and Technology
Chinese Center for Disease Control and Prevention
Københavns Universitet
University of Regina
Universidade Federal de Minas Gerais
Veterinary Research Institute, Brno
Hellenic Agricultural Organization-DIMITRAADA
National Center of Infectious and Parasitic Diseases Bulgaria
The University of Edinburgh
Általános Orvostudományi Kar
Fundacao Oswaldo Cruz
Shiraz University of Medical Sciences
Suez Canal University
IFREMER Institut Francais de Recherche pour l'Exploitation de la Mer
Technische Universität Dresden
University of Ghana
Canberra Hospital
Göteborgs Universitet
Robert Koch Institut
Kasturba Medical College, Manipal
University of Dhaka
Technical University of Denmark
Shantou University Medical College
Instituto de Salud Publica de Chile
Universidad Católica del Maule
Hong Kong Polytechnic University
University of Zagreb
University of Zagreb School of Medicine
University of Veterinary Medicine Budapest
Charles Darwin University
Austrian Agency for Health and Food Safety
Helsingin Yliopisto
Universidad Andrés Bello
Universidad de Buenos Aires
CI Tibaitatα
Apollo Diagnostics
Galαpagos
Universidad Catσlica Boliviana San Pablo
Polytechnic School of Abomey-Calavi (EPAC)
Laboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB)
Ministry of Health and Social Welfare
National Center for Disease Control and Public Health
ALS Water
BIOFOS A/S
Centre de Recherche en Sciences Naturelles (CRSN)
Ministry of Health
Public Health Institute of Republic of Srpska
Bridgetown
Athens Water Supply and Sewerage Company (EYDAP SA)
Other Contributor(s)
Abstract
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.