TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
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5
Issued Date
2020
Resource Type
Language
eng
File Type
application/pdf
Access Rights
open access
Rights
ผลงานนี้สงวนสิทธิ์โดยมหาวิทยาลัยมหิดล ห้ามทำซ้ำ คัดลอก หรือนำไปเผยแพร่ตัดต่อโดยมิได้รับอนุญาตเป็นลายลักษณ์อักษร
Rights Holder(s)
SYNTRAIN Consortuim and the University of Patras
Suggested Citation
Rakkreat Wikiniyadhanee, Tassanee Lerksuthirat, Wasana Stitchantrakul, Sermsiri Chitphuk, Thanyachai Sura, Donniphat Dejsuphong (2020). TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/97772
Title
TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells.
Abstract
Tripartite motif-containing protein 29 (TRIM29) is involved in DNA double-strand
break (DSB) repair. However, the specific roles of TRIM29 in DNA repair are not
clearly understood. To investigate the involvement of TRIM29 in DNA DSB repair, we
disrupted TRIM29 in DT40 cells by gene targeting with homologous recombination
(HR). Disrupting three alleles of TRIM29 not only decreased the recruitment of
53BP1, but also subsequently increased the recruitment of RAD51 to DNA DSBs in
response to DNA DSBs in vertebrate cells.
Description
SYNTRAIN CONFERENCE Genomic Instability in Cancer From tumour evolution to novel cures (online event).Organized by the SYNTRAIN Consortuim and the University of Patras, Greece. October 20-22, 2020
Sponsorship
Faculty of Graduate Studies, Mahidol University Academic Year 2018 and Thailand Research Fund (TRF5880149)