Publication: Ferrokinetics in patients with malaria: Haemoglobin synthesis and normoblasts in vitro
Issued Date
1976-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0017130386
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.70, No.3 (1976), 244-246
Suggested Citation
Tanomsri Srichaikul, Thitiporn Siriasawakul Ferrokinetics in patients with malaria: Haemoglobin synthesis and normoblasts in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.70, No.3 (1976), 244-246. doi:10.1016/0035-9203(76)90048-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10874
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Title
Ferrokinetics in patients with malaria: Haemoglobin synthesis and normoblasts in vitro
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Abstract
Bone marrow cultures in 15 Plasmodium falciparum patients were studied both during and after parasitaemia. Abnormalities were observed only in the group during parasitaemia. These abnormalities included: (1) decreased normoblastic number and cellular iron incorporation in all cases; (2) premature death of normoblasts during their development in the cultures in all cases; (3) defective haemoglobin synthesis in 3 of 11 cases (27%). A causal relationship between defective haemoglobin synthesis and degree of normoblastic destruction in the cultures was found. Marked anaemia and depressed C’ 3 level were found only in the group with defective haemoglobin synthesis. The significance of these findings is discussed. © 1976 Oxford University Press.