Publication: Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis
Issued Date
2012-04-15
Resource Type
ISSN
14643405
0960894X
0960894X
Other identifier(s)
2-s2.0-84859441948
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry Letters. Vol.22, No.8 (2012), 2902-2905
Suggested Citation
Sanya Sureram, Sarath P D Senadeera, Poonpilas Hongmanee, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis. Bioorganic and Medicinal Chemistry Letters. Vol.22, No.8 (2012), 2902-2905. doi:10.1016/j.bmcl.2012.02.053 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13759
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis
Abstract
Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. © 2012 Elsevier Ltd. All rights reserved.