Publication: Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats
Issued Date
1987-01-01
Resource Type
ISSN
03784274
Other identifier(s)
2-s2.0-0023132872
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Toxicology Letters. Vol.36, No.1 (1987), 95-103
Suggested Citation
Thirayudh Glinsukon, Wisuda Suvitayawat, Somphong Sahaphong, Pawinee Piyachaturawat Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats. Toxicology Letters. Vol.36, No.1 (1987), 95-103. doi:10.1016/0378-4274(87)90046-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15473
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effects of cytochalasin E on H+ and volume secretion in gastric fistula rats
Other Contributor(s)
Abstract
Effects of cytochalasin E on the secretion of H + and volume of gastric juice were investigated in gastric fistula rats. Direct exposure of the gastric mucosa to cytochalasin E (5-20 μg/ml) inhibited H + secretory rate in all of the pentagastrin-, histamine- as well as non-stimulated rats but it did not affect the secretory volume of gastric juice. The inhibitory action of cytochalasin E on H + secretion had a rapid onset and showed a dose-dependent pattern. The mechanism of inhibitory action was not related to its interaction with plasma membrane receptors or membrane enzyme, K + -stimulated ATPase. Interference with cellular energy production as well as alteration of microfilament function, which are essential for H + production and secretion respectively, are likely to be the bases of the cytochalasin inhibition. © 1987.