Publication: Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
Issued Date
2008-09-29
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ISSN
00404020
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2-s2.0-49549092692
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.64, No.40 (2008), 9636-9645
Suggested Citation
Nutchanat Phonkerd, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Kasem Soytong, Samran Prabpai, Palangpon Kongsearee Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05. Tetrahedron. Vol.64, No.40 (2008), 9636-9645. doi:10.1016/j.tet.2008.07.040 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18855
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Title
Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
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Abstract
Four new dimeric spiro-azaplilones, cochliodones A-D (1-4), two new azaphliones, chaetoviridines E and F (5 and 6), a new epi-chaetoviridin A (7), together with five known compounds, chaetoviridin A (8), ergosterol (9), chaetochalasin A (10), 24(R)-5α,8α-epidioxyergosta-6-22-diene-3β-ol (11), and ergosterol-β-d-glucoside (12) were isolated from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05. Structures and stereochemistry of the atropisomers 1-3 were determined by single-crystal X-ray diffraction analysis. Compounds 5, 10, and 11 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, 6, 10, and 11 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the KB, BC1, and NCI-H187 cell lines. © 2008 Elsevier Ltd. All rights reserved.