Publication:
Atropisomeric myristinins: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea

Issued Date

2002-08-09

Resource Type

Article

ISSN

00223263

DOI

10.1021/jo020045d

Other identifier(s)

2-s2.0-0037047548

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Organic Chemistry. Vol.67, No.16 (2002), 5470-5475

Suggested Citation

Supaporn Sawadjoon, Prasat Kittakoop, Kanyawim Kirtikara, Vanicha Vichai, Morakot Tanticharoen, Yodhathai Thebtaranonth Atropisomeric myristinins: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea. Journal of Organic Chemistry. Vol.67, No.16 (2002), 5470-5475. doi:10.1021/jo020045d Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20123

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Title

Atropisomeric myristinins: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea

Author(s)

Supaporn Sawadjoon
 Prasat Kittakoop
 Kanyawim Kirtikara
 Vanicha Vichai
 Morakot Tanticharoen
 Yodhathai Thebtaranonth

Other Contributor(s)

Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

The first naturally occurring atropisomeric flavans, myristinins B (2), ] (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH2Cl2 extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture of 4 and 4a, exhibited antifungal activity against Candida albicans with IC50 values ranging from 5.9 to 8.8 μg/mL, and they selectively inhibited the enzyme cyclooxygenase-2 (COX-2).

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20123

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Scopus 2001-2005