Publication: In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand
Issued Date
2004-04-01
Resource Type
ISSN
00029637
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2-s2.0-1942501224
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.70, No.4 (2004), 395-397
Suggested Citation
Kesinee Chotivanich, Rachanee Udomsangpetch, Wirongrong Chierakul, Paul N. Newton, Ronatrai Ruangveerayuth, Sasithon Pukrittayakamee, Sornchai Looareesuwan, Nicholas J. White In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand. American Journal of Tropical Medicine and Hygiene. Vol.70, No.4 (2004), 395-397. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21395
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Title
In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand
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Abstract
The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC50) values were quinine = 308 ng/mL, amodiaquine = 14 ng/mL, chloroquine = 50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.