Publication:
Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Issued Date

2006-09-01

Resource Type

Article

ISSN

00664804

DOI

10.1128/AAC.00774-05

Other identifier(s)

2-s2.0-33748685468

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Antimicrobial Agents and Chemotherapy. Vol.50, No.9 (2006), 3154-3156

Suggested Citation

Geraint R. Davies, Richard Brindle, Saye H. Khoo, Leon J. Aarons Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment. Antimicrobial Agents and Chemotherapy. Vol.50, No.9 (2006), 3154-3156. doi:10.1128/AAC.00774-05 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23635

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Title

Use of nonlinear mixed-effects analysis for improved precision of early pharmacodynamic measures in tuberculosis treatment

Author(s)

Geraint R. Davies
 Richard Brindle
 Saye H. Khoo
 Leon J. Aarons

Other Contributor(s)

University of Liverpool
 Portsmouth Hospitals
 University of Manchester
 Mahidol University

Abstract

Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Keyword(s)

Medicine
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/23635

Collections

Scopus 2006-2010