Publication: Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
Issued Date
2007-07-15
Resource Type
ISSN
0960894X
Other identifier(s)
2-s2.0-34250351179
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry Letters. Vol.17, No.14 (2007), 3826-3830
Suggested Citation
Koji Matsuoka, Chiharu Takita, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I.P.J. Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Ken Hatano, Daiyo Terunuma Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors. Bioorganic and Medicinal Chemistry Letters. Vol.17, No.14 (2007), 3826-3830. doi:10.1016/j.bmcl.2007.05.016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24163
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors
Abstract
A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases. © 2007 Elsevier Ltd. All rights reserved.