Publication: Co-stimulatory molecules on peripheral blood mononuclear cells and tissue infiltrating cells of skin wart and in vitro poke weed mitogen stimulation
Issued Date
2007-09-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-35848932095
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.90, No.9 (2007), 1879-1882
Suggested Citation
Potjaman Phumeesat, Somyot Charuwichitratana, Molvibha Vongsakul Co-stimulatory molecules on peripheral blood mononuclear cells and tissue infiltrating cells of skin wart and in vitro poke weed mitogen stimulation. Journal of the Medical Association of Thailand. Vol.90, No.9 (2007), 1879-1882. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24764
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Title
Co-stimulatory molecules on peripheral blood mononuclear cells and tissue infiltrating cells of skin wart and in vitro poke weed mitogen stimulation
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Abstract
Background: Skin wart is a lesion caused by human papilloma viruses (HPVs) that can infect both male and female. Objective: Quantify the number of CD28 +, CD86 +, CD152 + and γδ + in peripheral blood mononuclear cells (PBMCs) of subjects with skin wart. Identify CD86 + and γδ + cells in skin wart cryosections. Material and Method: Sixteen subjects with skin warts on face, hand, finger, knee, foot or plantar, both male and female, aged between 19-59 years-old, were recruited from Ramathibodi Hospital, Mahidol University, Bangkok Results: CD86 and CD152, on peripheral blood mononuclear cells (PBMCs) of subjects with skin wart are significantly lower compared to controls. Tissue cryosection staining for CD86 + and γδ + cells showed no difference among subjects with skin wart and control. Proliferative response to poke weed mitogen of subjects with skin wart is significantly lower than control subjects. Conclusion: There was no difference in the number of subjects positive for CD28 and CD86 + cell between normal and skin wart subject, but an increase in skin wart subjects with γδ + cells.