Publication: Thrombopoietin in Plasmodium falciparum malaria
Issued Date
2000-01-01
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ISSN
00071048
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2-s2.0-0034044675
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Mahidol University
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SCOPUS
Bibliographic Citation
British Journal of Haematology. Vol.109, No.3 (2000), 534-536
Suggested Citation
Anna Kreil, Christoph Wenisch, Gary Brittenham, Sornchai Looareesuwan, Markus Peck-Radosavljevic Thrombopoietin in Plasmodium falciparum malaria. British Journal of Haematology. Vol.109, No.3 (2000), 534-536. doi:10.1046/j.1365-2141.2000.02096.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26336
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Title
Thrombopoietin in Plasmodium falciparum malaria
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Abstract
Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal.