Publication: Characterisation and immuno-stimulating activity of polysaccharides from Thai medicinal plants
Issued Date
2010-09-20
Resource Type
ISSN
14786427
14786419
14786419
Other identifier(s)
2-s2.0-77956271426
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research. Vol.24, No.15 (2010), 1403-1412
Suggested Citation
J. Burana-Osot, K. Pattanapanyasat, N. Soonthornchareonnon, K. Sukapirom, T. Toida Characterisation and immuno-stimulating activity of polysaccharides from Thai medicinal plants. Natural Product Research. Vol.24, No.15 (2010), 1403-1412. doi:10.1080/14786410902940974 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28455
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Characterisation and immuno-stimulating activity of polysaccharides from Thai medicinal plants
Other Contributor(s)
Abstract
Water-soluble polysaccharides were isolated from the tubers of Butea superba Roxb. and Pueraria candollei Wall. Ex Benth. var. mirifica (Shaw et Suvat.) C. Niyomdham, the leaves of Centella asiatica (L.) Urb, Ocimum basilicum L., Psidium guajava and Andrographis paniculata (Burn. f.) Nees, the stems of Cymbopogon citratus (Stapf ExG), and the fruits of Psidium guajava and Scaphium scaphigerum. The immunological impacts of the polysaccharides on T-lymphocyte proliferation in vitro was investigated by flow cytometric (immunofluorescence) analysis using staphylococcal enterotoxin B (SEB) as a positive control. It was found that the polysaccharides enhanced T-lymphocyte proliferation, ranging from 4.5 to 27.0% at a concentration of 100 g mL-1, while the activity of SEB was 13.3%. The medicinal plants showing the highest immuno-stimulating activity were the tubers of Butea superba Roxb. The water-extracted tubers contained 60.0% (w/w) carbohydrates with 6.6% (w/w) uronic acid. The major constituent monosaccharides of the tubers were 28.2 mol% galactose, 10.5 mol% arabinose and 36.4 mol% glucose. © 2010 Taylor & Francis.