Publication: Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera
Issued Date
2010-05-28
Resource Type
ISSN
15206025
01633864
01633864
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2-s2.0-77952974771
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.73, No.5 (2010), 992-994
Suggested Citation
Joshua Parks, Thinley Gyeltshen, Vilailak Prachyawarakorn, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera. Journal of Natural Products. Vol.73, No.5 (2010), 992-994. doi:10.1021/np100078s Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28706
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Title
Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera
Abstract
Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia. © 2010 The American Chemical Society and American Society of Pharmacognosy.