Publication: Hb tak and Hb Q-Thailand in thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography
Issued Date
2010-04-01
Resource Type
ISSN
1532432X
03630269
03630269
Other identifier(s)
2-s2.0-77950482755
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Mahidol University
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SCOPUS
Bibliographic Citation
Hemoglobin. Vol.34, No.2 (2010), 161-164
Suggested Citation
Sumalee Jindadamrongwech, Noppawan Tungbuppha, Suporn Chuncharunee, Punnee Butthep Hb tak and Hb Q-Thailand in thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography. Hemoglobin. Vol.34, No.2 (2010), 161-164. doi:10.3109/03630261003679631 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28743
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Title
Hb tak and Hb Q-Thailand in thai patients are S-window hemoglobin variants revealed by high performance liquid chromatography
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Abstract
The S-window hemoglobin (Hb) variants revealed by high performance liquid chromatography (HPLC) were studied in 12 Thai individuals. The variants were identified, using DNA sequencing and multiplex amplification refractory mutation system-polymerase chain reaction (ARMS-PCR), to be six cases of Hb Tak [β147 (AC)], and six cases of Hb Q-Thailand [α74(EF3)Asp→His], respectively. By using the Capillarys 2-capillary zone electrophoresis (CE), Hb Tak and Hb Q-Thailand co-migrated with Hb F in zone 7. This might pose a problem as the high Hb F conditions suggest a differential diagnosis. The S-window Hb variants are mostly Hb Tak and Hb Q-Thailand in the Thai population rather than Hb S [β6(A3)Glu→Val]. The definite identification of Hb variants detected by HPLC or capillary electrophoresis (CE) requires DNA analysis. © Informa UK, Ltd.