Publication: Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense
Issued Date
2014-01-01
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ISSN
15559475
1934578X
1934578X
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2-s2.0-84905110963
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.9, No.7 (2014), 929-932
Suggested Citation
Sakchai Hongthong, Chutima Kuhakarn, Vichai Reutrakul, Surawat Jariyawat, Pawinee Piyachaturawat, Narong Nuntasaen, Thaworn Jaipetch Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense. Natural Product Communications. Vol.9, No.7 (2014), 929-932. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33151
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Title
Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense
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Abstract
Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.