Publication:
Synthesis and biological evaluation of simplified analogs of lophocladine B as potential antitumor agents

Issued Date

2016-12-01

Resource Type

Article

ISSN

15548120
10542523

DOI

10.1007/s00044-016-1717-5

Other identifier(s)

2-s2.0-84987625036

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Medicinal Chemistry Research. Vol.25, No.12 (2016), 2959-2964

Suggested Citation

Sewan Theeramunkong, Opa Vajragupta, Chawannuch Mudjupa Synthesis and biological evaluation of simplified analogs of lophocladine B as potential antitumor agents. Medicinal Chemistry Research. Vol.25, No.12 (2016), 2959-2964. doi:10.1007/s00044-016-1717-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43358

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Title

Synthesis and biological evaluation of simplified analogs of lophocladine B as potential antitumor agents

Author(s)

Sewan Theeramunkong
 Opa Vajragupta
 Chawannuch Mudjupa

Other Contributor(s)

Thammasat University
 Mahidol University
 Mahasarakham University

Abstract

© 2016, Springer Science+Business Media New York. In this study, two series of simplified isoquinolines deriving from lophocladine B were synthesized and evaluated for their antitumor activity. Suzuki-Miyaura and Sharpelss-Fokin reactions were employed to synthesize 26 compounds. Two compounds (25 and 27) showed to be cytotoxic with IC50 values of 10 µM on hepatic cancer cells and 13 µM on cervical cancer cells, respectively. Further studies on their mechanism of action showed that compound 27 mediated cytotoxicity through apoptosis induction.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/43358

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Scopus 2016-2017