Publication: Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)
Issued Date
2019-01-01
Resource Type
ISSN
20499442
20499434
20499434
Other identifier(s)
2-s2.0-85062662624
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Mahidol University
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SCOPUS
Bibliographic Citation
Biomedical Reports. Vol.10, No.3 (2019), 147-155
Suggested Citation
Juthamas Yosudjai, Sopit Wongkham, Siwanon Jirawatnotai, Worasak Kaewkong Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review). Biomedical Reports. Vol.10, No.3 (2019), 147-155. doi:10.3892/br.2019.1188 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50396
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Title
Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review)
Abstract
© 2019, Spandidos Publications. All rights reserved. Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post‑transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed.