Mapping the immune response to burkholderia mallei during experimental equine glanders infection
Issued Date
2004
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Rachaneeporn Tiyawisutsri, รัชนีพร ติยะวิสุทธิ์ศรี, Clarke, Simon, Foster, Simon, Narisara Chantratita, นริศรา จันทราทิตย์, White, Nicholas J, Day, Nicholas PJ, Woods, Don, Peacock, Sharon J (2004). Mapping the immune response to burkholderia mallei during experimental equine glanders infection. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/63414
Title
Mapping the immune response to burkholderia mallei during experimental equine glanders infection
Abstract
Burkholoderia mallei is the cause of glanders Human infection is extremely. Rare, but renewed interesting parallels the realization that this organism could be used as an agent of bioterrorism. There is a need to develop an effective vaccine, and the purpose of this project was to inform this effort by mapping the immune response to B. Mallei during experimental equine infection. An expression library was constructed using the B. mallei sequence strain 23344 and a phagemid vector expression system. This was used to screen sera from two horses with experimental glanders infected with B mallei 23344. More than 140 inserts were sequenced, 30 of which were unique. These included surface expressed and Transmemembrane proteins secreted proteins and hydoprotheical proteins. This technique represents a powerful tool for the elucidation of novel putative vaccine candiddates….
Description
Joint International Tropical Medicine Meeting 2004: Ambassador Hotel, Thailand 29 November-1 December 2004: abstract. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2004. p.263.