Scopus 2024
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- ItemSEGSRNet for Stereo-Endoscopic Image Super-Resolution and Surgical Instrument Segmentation(2024-01-01) Hayat M.; Aramvith S.; Achakulvisut T.; Hayat M.; Mahidol UniversitySEGSRNet addresses the challenge of precisely identifying surgical instruments in low-resolution stereo endoscopic images, a common issue in medical imaging and robotic surgery. Our innovative framework enhances image clarity and segmentation accuracy by applying state-of-the-art super-resolution techniques before segmentation. This ensures higher-quality inputs for more precise segmentation. SEGSRNet combines advanced feature extraction and attention mechanisms with spatial processing to sharpen image details, which is significant for accurate tool identification in medical images. Our proposed model, SEGSRNet, surpasses existing models in evaluation metrics including PSNR and SSIM for super-resolution tasks, as well as IoU and Dice Score for segmentation. SEGSRNet can provide image resolution and precise segmentation which can significantly enhance surgical accuracy and patient care outcomes.
- ItemData Analytics and Visualization in Bimanual Rehabilitation Monitoring Systems: A User-Centered Design Approach to Healthcare Professionals Decision Support(2024-01-01) Wisedsri P.; Anutariya C.; Sujarae A.; Vachalathiti R.; Bovonsunthonchai S.; Wisedsri P.; Mahidol UniversityThis study presents the design of a user-centered data visualization dashboard for stroke rehabilitation, which integrates the principles of visualization data analytics techniques in the field of healthcare. Addressing the complexities of visualizing for robotic bimanual rehabilitation, the design introduces novel methods to enhance data visualization, broadening monitoring capabilities, and improving the clarity of torque data. These enhancements lead to a clearer understanding of patient robot interactions. A prototype has been developed to visualize transparent torque data from a bimanual master slave robotic system, enabling healthcare professionals to monitor patient progress effectively. The dashboard features intuitive visual representations of master, slave, and assistive torques, simulating elbow joint movements through line and sunburst charts. Feedback from rehabilitation therapists during the design process ensures that the visualization approach is aligned with clinical needs. The findings suggest that the system can assist physiotherapists in devising personalized treatment strategies by providing actionable insights from the recorded data. However, additional research is needed to integrate real clinical data into the system for further enhancement and validation. This innovation has the potential to significantly improve stroke rehabilitation effectiveness and patient outcomes through a bimanual rehabilitation visualization and decision support system.
- ItemIncreased Risk of Stroke in Constipation Patients Systematic Review and Meta-analysis(2024-01-01) Suenghataiphorn T.; Yanpiset P.; Xanthavanij N.; Srikulmontri T.; Thiravetyan B.; Tribuddharat N.; Prasitsumrit V.; Danpanichkul P.; Sodsri T.; Kulthamrongsri N.; Wattanachayaku P.; Suenghataiphorn T.; Mahidol UniversityObjective: Constipation is commonly seen among patients with cardiovascular diseases and is linked to adverse outcomes. However, the association between constipation and the risk of stroke remains conflicting. Therefore, we aim to conduct a systematic review and meta-analysis to summarize the available data on this topic. Methods: We identified potentially eligible studies from the MEDLINE and EMBASE databases, searching from inception to May 2024, to investigate the association between constipation and stroke. To be included, studies needed to compare the incidence of stroke between groups with and without constipation. Effect size and 95% CIs were combined using the generic inverse variance method. Results: Our meta-analysis included 8 studies that met the eligibility criteria. There were 5,360,573 participants, with a mean age of 53.9 years and 69% are males. We found that patients with constipation have a 41% increased risk of stroke with a pooled risk ratio of 1.41 (95% CI: 1.13-1.75; P < 0.01, I2 = 99%) compared with those without constipation. Subgroup analysis revealed that patients with constipation have a 50% increased risk of ischemic stroke with a pooled risk ratio of 1.50 (95% CI: 1.15-1.96; P < 0.01, I2 = 99%), but no statistical significance was found for mixed-type stroke outcome. Conclusions: Our study revealed that constipation is associated with a higher risk of stroke. These findings could influence future strategies for cardiovascular disease prevention and management in patients with chronic constipation.
- ItemFull-Endoscopic Midline Foraminoplasty: An Alternative Method for Treating Lumbar Foraminal Stenosis(2024-12-01) Pairuchvej S.; Keorochana G.; Jitpakdee K.; Rittipoldechs C.A.; Kongthavornsakul J.; Pairuchvej S.; Mahidol UniversityObjective: To describe the full-endoscopic lumbar foraminoplasty with midline skin incision (FEFM) and lateral recess decompression procedure and to report its clinical outcomes at the 1-year follow-up. Methods: Consecutive patients with lumbar foraminal and/or lateral recess stenosis who underwent FEFM procedures were retrospectively reviewed. Clinical outcomes were evaluated with a visual analogue scale (VAS) of back and leg pain and Oswestry Disability Index (ODI) up to 1 year postoperatively. The complications and recurrence rate were also recorded. Results: A total of 30 cases (51 levels) were included (L3–4, 6 cases [11.8%]; L4–5, 23 [45.1%]; L5–S1, 22 cases [43.1%]). VAS scores collected at preoperative, postoperative day 1, 3 months, 6 months, and 1 year were 9.16, 1.7, 1.36, 1.3, and 1.43, respectively. The ODI scores collected at preoperative, postoperative 3 months, 6 months, and 1 year were 46.63, 11.5, 10.66, and 10.46, respectively (p < 0.05). The mean operation time was 88.7 minutes (range, 45–152 minutes). The length of hospital stay was 1.21 days (range, 1–3 days). No immediate complications were identified, and no patients experienced a recurrence of symptoms requiring revision surgery. Conclusion: FEFM is an effective procedure for treating foraminal and/or lateral recess stenosis. It demonstrates the capability to decompress both bilateral foraminal and lateral recess stenosis through a single-entry point.
- ItemChronic cough management: Practical guidelines and PICO-based evidence for treatment(2024-12-01) Kanjanawasee D.; Poachanukoon O.; Sriprasart T.; Chirakalwasan N.; Saiphoklang N.; Athipongarporn A.; Senavonge A.; Kamalaporn H.; Sanguanwong N.; Mitthamsiri W.; Chiewchalermsri C.; Suetrong B.; Suwanchanratsamee A.; Tantilipikorn P.; Maneerattanaporn M.; Jaruchinda P.; Kawamatawong T.; Luvira V.; Sombuntham P.; Sompornrattanaphan M.; Suwanwech T.; Chotchai N.; Ruxrungtham K.; Boonsawat W.; Brannan J.D.; Song W.J.; Pornsuriyasak P.; Kanjanawasee D.; Mahidol UniversityThis part reviews the management of chronic cough and proposes a management algorithm. Despite proven improvements in quality of life following chronic cough treatment, a clear understanding of the disease and the evidence for the efficacy of some treatments remain vague. Eight key questions regarding the treatment in the uncertain areas were systematically addressed based on the PICO framework and applying the GRADE system for evidence synthesis to provide the strength of recommendation and quality of evidence for key questions, with narrative components for the description of other chronic cough treatment including non-pharmacological therapy. Practical diagrams were developed to facilitate clinical decision-making on treatment. Our guideline introduces the concept of the cough management process for guiding practitioners to assess chronic cough using a holistic approach.
- ItemSkin prick test and serum specific IgE in predicting dust mite-induced allergic rhinitis diagnosed from nasal provocation test in chronic rhinitis children(2024-12-01) Klangkalya N.; Kanchongkittiphon W.; Sawatchai A.; Kiewngam P.; Jotikasthira W.; Manuyakorn W.; Klangkalya N.; Mahidol UniversityBACKGROUND: Allergen skin prick test (SPT) and serum specific immunoglobulin E (sIgE) are effective diagnostic tests in allergic rhinitis (AR), however, positive results may not always correlate with clinical allergies. A nasal provocation test (NPT) can identify the causative allergen for immunotherapy, but it's not routinely performed. OBJECTIVE: To establish the cutoff value for the house dust mite (HDM) SPT mean wheal diameter (MWD) and HDM sIgE level for identifying children with HDM-induced AR diagnosed from NPT. METHODS: Children aged 5 to 18 years old with chronic rhinitis were evaluated by HDM SPT, sIgE, and NPT. Children with positive NPT results indicated HDM-induced AR. The cutoff values of the HDM SPT and sIgE level for predicting positive NPT were determined using a receiver operating characteristic curve. RESULTS: A total of 245 children with a mean age of 9.53 ± 3 years were enrolled. HDM SPT results were positive (≥ 3 mm) in 160 (65.3%) children. HDM NPT results were positive in 176 (71.8%) children. Among children with positive HDM SPT (n = 160), 153 children (95.6%) were confirmed as having AR on NPT findings. The cutoff values for positive NPT responses were 6.6 mm for HDM SPT (yielding 100% specificity and 100% positive predictive value) and 17.0 kUA/L for sIgE (98.6% specificity and 99.2% positive predictive value). CONCLUSIONS: This study proposes HDM SPT and sIgE cutoff values for use in the diagnosis of HDM-induced AR based on NPT. These cutoff values can be used to identify HDM-induced AR children who might benefit from immunotherapy.
- ItemChanges in the prognosis of CADASIL over time: a 23-year study in 555 individuals(2024-01-01) Sukhonpanich N.; Koohi F.; Jolly A.A.; Markus H.S.; Sukhonpanich N.; Mahidol UniversityBackground Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of stroke and is associated with early-onset stroke and dementia. Whether its clinical phenotype is becoming milder with better risk factor treatments and other care improvements is unknown. In a large longitudinal CADASIL cohort, we determined whether the prognosis has changed over 23 years. Methods Patients were identified from the Cambridge CADASIL register and the UK Familial stroke study. Change in age at stroke over the time of recruitment was determined using linear mixed-effects model, and the impact of genetic and vascular risk factors on stroke and dementia risk was further evaluated using Cox proportional hazard regression. Results A total of 555 patients with CADASIL were recruited between 2001 and 2023. The age of stroke onset significantly increased over time (p<0.001), with the mean age of stroke onset for patients recruited before 2016 (n=265) at 46.7±9.2 years and 51.6±9.5 years for those recruited since 2016 (n=290). Patients recruited since 2016 had lower risks of both stroke (HR 0.36, 95% CI 0.26 to 0.50, p<0.001) and dementia (HR 0.43, 95% CI 0.19 to 0.99, p=0.046) after adjusting for sex, hypertension history, smoking status, epidermal growth factor-like repeat position and calendar effect. Conclusions The clinical phenotype of CADASIL is improving. While this may be partly explained by reduced vascular risk factors such as smoking and the identification of milder cases, differences persisted after controlling for risk factors and mutation sites. These updated risk estimates should be used when counselling patients with CADASIL on prognosis.
- ItemFish Protein Hydrolysates: From Production to Food and Nutraceutical Industry Applications(2024-01-01) Nirmal N.; Santivarangkna C.; Bekhit A.E.D.A.; Barba F.J.; Nirmal N.; Mahidol UniversityFish Protein Hydrolysates: From Production to Food and Nutraceutical Industry Applications provides the most updated and comprehensive knowledge on fish protein hydrolysate production using a variety of innovative processing techniques and technologies. This book highlights various biological activities and health benefits of fish protein hydrolysates, their food and nutraceutical industry applications, and associated safety concerns. Written by international experts in the field of fisheries and seafood processing, this book provides its readership with a wealth of recent developments and guidance on each production method, including current and emerging technologies. This book discusses the defatting and debittering aspects of fish protein hydrolysates, purification methods, trends in food product development, food and feed applications, and more. Most importantly, this book provides real-time industrial scale-up process, commercialization, safety, and regulatory issue of fish protein hydrolysate as a food ingredient. Fish Protein Hydrolysates: From Production to Food and Nutraceutical Industry Applications is a valuable resource for fish processing industries, researchers, or scientists to update their knowledge on production techniques, bittering issues of fish protein hydrolysates, and scale-up processes. In addition, this is a valuable source for academic scholars and students to keep up to date with the current changes and improvements in fish protein hydrolysate production and applications in the food industry. Key Features Provides methods to utilize low-value fish discards and minimize seafood processing waste Discusses current technologies and the impact of different processing parameters on fish protein hydrolysate production Explains the de-bittering process, functional properties, bioactivities, food applications, and health benefits of fish protein hydrolysates Outlines food safety concerns and regulation of fish protein hydrolysate as a food ingredient.
- ItemInternalization of cell-derived microparticles triggers endothelial pro-inflammatory responses(2024-12-01) Klaihmon P.; Khuhapinant A.; Kheansaard W.; Pattanapanyasat K.; Klaihmon P.; Mahidol UniversityBACKGROUND: Increased numbers of circulating microparticles (MPs) have long been documented in thalassemia and are considered as a contributing factor in developing the thromboembolic events (TEEs), which are associated with endothelial dysfunction. Indeed, the cellular and molecular mechanisms by which MPs and endothelial cells interact and their consequences remain poorly investigated. OBJECTIVE: The present study aims to compare the biological effects of MPs obtained from healthy subjects and β-thalassemia/HbE patients on endothelial pro-inflammatory responses. METHODS: MPs isolated from plasma by two-step centrifugation from 10 healthy donors, 19 splenectomized and 30 non-splenectomized β-thalassemia/HbE patients were first characterized for their cellular origins, then counted and incubated with primary human umbilical vein endothelial cells (HUVECs). Internalization of MPs into HUVECs and their induction on endothelial cell activation and pro-inflammatory responses were determined. RESULTS: MPs either from healthy or β-thalassemia/HbE patients could become internalized into endothelial cells, but unlike MPs from healthy donors and non-splenectomized patients, MPs from splenectomized patients were the most active and induced the 2-fold up-regulation of pro-inflammatory genes, IL1B, CXCL8, and CCL2 and 4-fold increase in interleukin-1β. In addition, MPs from both healthy subjects and splenectomized patients at 106/ml failed to trigger the secretion of endothelial IL-6 and IL-8 while higher MP concentration at 5 × 10⁶/ml significantly induced this secretion. CONCLUSIONS: Plasma MPs isolated from splenectomized β-thalassemia/HbE patients are capable of triggering pro-inflammatory responses from endothelial cells reflected at both gene and protein levels.
- ItemChronic cough management: Practical guidelines and PICO-based evidence for screening and investigation(2024-12-01) Kanjanawasee D.; Poachanukoon O.; Sriprasart T.; Chirakalwasan N.; Saiphoklang N.; Athipongarporn A.; Senavonge A.; Kamalaporn H.; Sanguanwong N.; Mitthamsiri W.; Chiewchalermsri C.; Suetrong B.; Suwanchanratsamee A.; Tantilipikorn P.; Maneerattanaporn M.; Jaruchinda P.; Kawamatawong T.; Luvira V.; Sombuntham P.; Sompornrattanaphan M.; Suwanwech T.; Chotchai N.; Ruxrungtham K.; Boonsawat W.; Brannan J.D.; Song W.J.; Pornsuriyasak P.; Kanjanawasee D.; Mahidol UniversityChronic cough is a common clinical condition requiring comprehensive assessment. This review employs a symptom-focused approach, prioritizing the presenting symptom of "chronic cough" to mirror real-world clinical practice. Ten key questions regarding the investigations in the uncertain areas were systematically addressed based on the PICO framework and applying the GRADE system for evidence synthesis to provide the strength of recommendation and quality of evidence for key questions. Practical diagrams were developed to facilitate clinical decision-making. The initial evaluation involves screening for red flag signs requiring urgent attention, followed by a detailed history-taking and physical examination. A chest radiograph is recommended as the first-line investigation. The primary objective of the initial evaluation is to identify the cause and initiate appropriate treatment. If history and physical examination prove insufficient for a definitive diagnosis, referral to a specialist is advised for further specific testing. The recommendations on specific testing include fractional exhaled nitric oxide for cough variant asthma, nasal endoscopy or digital endoscopy (optional) for upper airway cough syndrome, paranasal sinus computed tomography (CT) for chronic rhinosinusitis, and laryngoscopy for hoarseness. Spirometry is for the diagnosis of obstructive airway diseases, and peak flow variability or bronchial challenge tests are complements particularly if asthma is suspected. Gastroesophageal reflux (GERD) investigations are for patients with chronic cough without typical GERD symptoms. Sinus radiographs and chest CT are not routinely recommended. Our guideline distinguishes itself by prioritizing a symptom-based clinical evaluation to guide clinicians toward the most probable diagnosis, streamlining the diagnostic process.