Publication:
EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA

Issued Date

1986-03-29

Resource Type

Article

ISSN

01406736

DOI

10.1016/S0140-6736(86)91103-7

Other identifier(s)

2-s2.0-0022593162

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

The Lancet. Vol.327, No.8483 (1986), 713-716

Suggested Citation

R. E. Phillips, S. Looareesuwan, S. R. Bloom, D. A. Warrell, R. C. Turner, D. Quantrill, A. R. Moore EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA. The Lancet. Vol.327, No.8483 (1986), 713-716. doi:10.1016/S0140-6736(86)91103-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9809

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Title

EFFECTIVENESS OF SMS 201-995, A SYNTHETIC, LONG-ACTING SOMATOSTATIN ANALOGUE, IN TREATMENT OF QUININE-INDUCED HYPERINSULINAEMIA

Author(s)

R. E. Phillips
 S. Looareesuwan
 S. R. Bloom
 D. A. Warrell
 R. C. Turner
 D. Quantrill
 A. R. Moore

Other Contributor(s)

Mahidol University
 John Radcliffe Hospital
 Hammersmith Hospital

Abstract

SMS 201-995, a new long-acting, synthetic somatostatin analogue, dose 50 μg/h, given as a continuous intravenous infusion, completely abolished quinine-induced insulin release in 9 healthy Thai volunteers. Hyperinsulinaemia, which caused sustained hypoglycaemia in a 32-year-old post-partum Thai patient who was receiving intravenous quinine for falciparum malaria, was suppressed within 30 min of starting SMS 201-995, and the patient became fully conscious. This octapeptide antagonises the stimulatory effect of quinine on the pancreatic beta cell and is a specific therapy for life-threatening hyperinsulinaemic hypoglycaemia complicating falciparum malaria. © 1986.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/9809

Collections

Scopus 1969-1990