Publication:
The toxicity of betel nut extract determined by inhibition of microbial dehydrogenase activity

Issued Date

1986-01-01

Resource Type

Article

ISSN

10982256
08848181

DOI

10.1002/tox.2540010404

Other identifier(s)

2-s2.0-0022904935

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Toxicity Assessment. Vol.1, No.4 (1986), 419-429

Suggested Citation

Sittichai Koontongkaew, Boonyanit Thaweboon, Rungsunn Tungtrongchitr The toxicity of betel nut extract determined by inhibition of microbial dehydrogenase activity. Toxicity Assessment. Vol.1, No.4 (1986), 419-429. doi:10.1002/tox.2540010404 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9873

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Title

The toxicity of betel nut extract determined by inhibition of microbial dehydrogenase activity

Author(s)

Sittichai Koontongkaew
 Boonyanit Thaweboon
 Rungsunn Tungtrongchitr

Other Contributor(s)

Mahidol University

Abstract

Dimethyl sulfoxide extracts of betel nut (100g/L) and betel leaf (100g/L), and methanol and water extracts of betel nut (100g/L) were found to inhibit dehydrogenase activity of Bacillus subtilis. In contrast betel nut (100g/L) extracted by petroleum ether showed no inhibitory effect. Thin layer chromatography, ultraviolet spectroscopy and total polyphenols estimation indicated that betel nut contained large amounts of polyphenols. On the basis of toxicity assessment, the results implied that betel nuts and betel leaves contained a hydrophilic element which was toxic to living cells. Copyright © 1986 Wiley Periodicals, Inc., A Wiley Company

Keyword(s)

Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/9873

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Scopus 1969-1990