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Publication Metadata only Sequential open-label study of the safety, tolerability, and pharmacokinetic interactions between dihydroartemisinin-piperaquine and mefloquine in healthy Thai adults(2019-01-01) Borimas Hanboonkunupakarn; Rob W. Van Der Pluijm; Richard Hoglund; Sasithon Pukrittayakamee; Markus Winterberg; Mavuto Mukaka; Naomi Waithira; Kesinee Chotivanich; Pratap Singhasivanon; Nicholas J. White; Arjen M. Dondorp; Joel Tarning; Podjanee Jittamala; Mahidol University; Nuffield Department of Clinical Medicine; Royal Society of Thailandinterval [CI], -33.1, -10.4; P=0.0039) and maximum concentration of drug in serum (-29.0%; 90% CI, -40.6, -15.1; P=0.0079). Mefloquine can be added safely to dihydroartemisinin-piperaquine in malaria treatment.Publication Metadata only Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy(2003-05-01) Mathieu Nacher; Rose McGready; Kasia Stepniewska; Thein Cho; Sornchai Looareesuwan; Nicholas J. White; François Nosten; Mahidol University; Shoklo Malaria Research Uniton the north-western border of Thailand between 1993 and 1997. The development of Plasmodium vivax malaria was associated with a past mean haematocrit, > 30% (hazard ratio = 1.5, 95% CI 1.2-2, P = 0.001) and recent (≤ 30 d) iron and folate supplementation... (hazard ratio = 1.7, 95% CI 1.1-2.6, P= 0.01). There were no associations with P. falciparum infections. Plasmodium vivax has a predilection for young erythrocytes, and these results suggest that pregnant women with larger numbers of circulating young redPublication Metadata only A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos(2003-05-01) Mayfong Mayxay; Rattanaxay Phetsouvanh; Samlane Phompida; Paul N. Newton; Maniphone Khanthavong; Bouakham Vannachone; Alan Brockman; Nicholas J. White; National University of Laos; Mahosot Hospital; Parasitology and Entomology; John Radcliffe Hospital; Mahidol University; Shoklo Malaria Research UnitBetween June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years...). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently. © 2003 Royal Society of Tropical Medicine and Hygiene.Publication Metadata only Activation of the coagulation cascade in patients with leptospirosis(2008-01-15) Wirongrong Chierakul; Panatsaya Tientadakul; Yupin Suputtamongkol; Vanaporn Wuthiekanun; Kriangsak Phimda; Roongrueng Limpaiboon; Nisarat Opartkiattikul; Nicholas J. White; Sharon J. Peacock; Nicholas P. Day; Mahidol University; Udon Thani Center Hospital; Nuffield Department of Clinical MedicineOrgan Failure Assessment scores and more bleeding complications. Nearly one-half of patients with leptospirosis had overt DIC as defined by an International Society on Thrombosis and Hemostasis DIC score. Conclusions. Activation of the coagulation system... is an important feature of leptospirosis. Thrombocytopenia is an indicator of severe disease and risk of bleeding. © 2007 by the Infectious Diseases Society of America. All rights reserved.Publication Metadata only Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations(2006-02-01) Paul N. Newton; Steven Ward; Brian J. Angus; Wirongrong Chierakul; Arjen Dondorp; Ronnatrai Ruangveerayuth; Kamolrat Silamut; Pramote Teerapong; Yupin Suputtamongkol; Sornchai Looareesuwan; Nicholas J. White; Mahidol University; Churchill Hospital; Liverpool School of Tropical Medicine; Mae Sot General Hospital; Faculty of Medicine, Siriraj Hospital, Mahidol Universitysporadic reports of quinine treatment failures in severe malaria. © 2005 Royal Society of Tropical Medicine Hygiene. Published by Elsevier Ltd. All rights reserved.Publication Metadata only A systematic overview of published antimalarial drug trials(2004-01-01) Hla Yin Myint; Prakaykaew Tipmanee; François Nosten; Nicholas P.J. Day; Sasithon Pukrittayakamee; Sornchai Looareesuwan; Nicholas J. White; Mahidol University; Shoklo Malaria Research Unit; John Radcliffe HospitalRoyal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Artesunate-dapsone-proguanil treatment of falciparum malaria: Genotypic determinants of therapeutic response(2005-02-01) Sivicha Krudsood; Mallika Imwong; Polrat Wilairatana; Sasithon Pukrittayakamee; Apichart Nonprasert; Georges Snounou; Nicholas J. White; Sornchai Looareesuwan; Mahidol University; Institut Pasteur, Paris; John Radcliffe Hospitalrates were high. Proguanil is inexpensive, widely available and very similar to chlorproguanil. The safety and efficacy of artesunate-dapsone-proguanil (artesunate 4 mg/kg, dapsone 2.5 mg/kg, proguanil 8 mg/kg daily for three days), was studied... considerably augments the anti-malarial activity of the biguanide-dapsone combination, but this is insufficient for infections with parasites carrying the highly antifol-resistant Pfdhfr I164L mutation. © 2004 Royal Society of Tropical Medicine and HygienePublication Metadata only Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand(2006-01-01) Allen C. Cheng; Sharon J. Peacock; Direk Limmathurotsakul; Gumphol Wongsuvan; Wirongrong Chierakul; Premjit Amornchai; Nongluk Getchalarat; Wipada Chaowagul; Nicholas J. White; Nicholas P.J. Day; Vanaporn Wuthiekanun; Mahidol University; Menzies School of Health Research; Sappasitthiprasong Hospital; Nuffield Department of Clinical Medicine; Geelong HospitalSociety of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.Publication Metadata only Optimising operational use of artesunate-mefloquine: A randomised comparison of four treatment regimens(2004-03-01) Frank Smithuis; Ingrid van der Broek; Nina Katterman; Moe Kyaw Kyaw; Alan Brockman; Saw Lwin; Nicholas J. White; Medecins sans Frontieres; Mahidol University; John Radcliffe Hospital. During 42 days follow-up polymerase chain reaction genotyping-confirmed recrudescence occurred in 11 of 187 (5.9%) patients who received observed single low-dose mefloquine (15 mg/kg) and artesunate (4 mg/kg), 7 of 192 (3.6%) patients following observed... single high-dose mefloquine (25 mg/kg) and artesunate (4 mg/kg), 7 of 180 (3.9%) patients following observed artesunate 4 HSP mg/kg on day 0 plus self-administered mefloquine 15 mg/kg on day 1 and 10 mg/kg on day 2 with artesunate 4 mg/kg/day on day 1Publication Metadata only Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum(2005-07-01) Varunee Desakorn; Arjen M. Dondorp; Kamolrat Silamut; Wirichada Pongtavornpinyo; Duangjai Sahassananda; Kesinee Chotivanich; Punnee Pitisuttithum; A. M. Smithyman; Nicholas P J Day; Nicholas J. White; Mahidol University; Nuffield Department of Clinical Medicine; Cellabs Pty Ltd.to parasite age was developed to facilitate this. In four isolates of P. falciparum, the median (range) PfHRP2 content was 2.0 fg (0.5-4.3 fg) for a young ring stage infected erythrocyte, and 5.4 fg (2.1-10.2 fg) for the schizont stage. The amount of PfHRP2... in the parasitized erythrocyte increased most during development to the mature trophozoite stage. The median (range) amount of PfHRP2 secreted per parasite per entire erythrocytic cycle was 5.2 fg (1.1-13.0 fg). A median of 89% of the total PfHRP2 was excreted