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Publication Open Access Factors Related to Functional Status in Patients with Rheumatoid Arthritis(2017) Tran Thi Ngoc Xuyen; วิมลรัตน์ ภู่วราวุฒิพานิช; Wimolrat Puwarawuttipanit; วัลย์ลดา ฉันท์เรืองวณิชย์; Wallada Chanruangvanich; มหาวิทยาลัยมหิดล. คณะพยาบาลศาสตร์; มหาวิทยาลัยมหิดล. คณะพยาบาลศาสตร์. ภาควิชาการพยาบาลศัลยศาสตร์; มหาวิทยาลัยมหิดล. คณะพยาบาลศาสตร์. ภาควิชาการพยาบาลอายุรศาสตร์Purpose: To study the relationships between self-efficacy, pain level, depression, social support, and functional status among patients with rheumatoid arthritis. Design: Descriptive correlational design. Methods: The sample was 126... studied variables. Main findings: The findings supported the proposed hypotheses that self-efficacy and social support were negatively related to functional status (disability score) in patients with rheumatoid arthritis (rs = - .349, - .215, p < .05Publication Open Access Clinical Outcomes of Early Intensive Treatment of Rheumatoid Arthritis(2015) Prapan Booranaburidej; Parawee Suwannalai; Passawee Wananuwat; Umaporn Udomsupayakul; Kanokrat Nantiruj; ประพันธ์ บูรณบุรีเดช; ปารวี สุวรรณาลัย; พัสวี วนานุวัธ; อุมาพร อุดมทรัพยากุล; กนกรัตน์ นันทิรุจ; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Medicine; Police General Hospital. Medicine Department; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Section for Clinical Epidemiology and BiostatisticsIntroduction: As learnt from previous international early arthritis cohort, early remission is the treatment target for rheumatoid arthritis. To reach that outcome, early intervention with adequate DMARDs is crucial especially in the first year... of disease. Objective: We evaluate the efficacy of combination DMARDs and tight control strategy in early rheumatoid arthritis patients of Ramathibodi Hospital. Methods: Early RA patients (onset < 1 years) were enrolled to the tight control treatmentPublication Open Access The dementia and disability project in Thai elderly: rational, design, methodology and early results(2013) Vorapun Senanarong; Kamolthip Harnphadungkit; Niphon Poungvarin; Sathit Vannasaeng; Samut Chongwisal; Tipa Chakorn; Piyanuch Jamjumrus; Atthapon Raksthaput; Sinisa Chaichanettee; Nattapol Aoonkaew; Suthipol Udompunthurak; Doody, Rachelle S.; Cummings, Jeffrey L.; Mahidol University. Faculty of Medicine Siriraj Hospital.chronic diseases in the Thai population, cerebrovascular diseases, diabetes, and arthritis are common. These factors are known to contribute to disability and poor quality of life in the elder population. Neuropsychiatric problems, cognitive declinePublication Open Access Overexpression of receptor for advanced glycation end products and high-mobility group box 1 in human dental pulp inflammation.(2014-07-10) Salunya Tancharoen; ศรัณยา ตันเจริญ; Tassanee Tengrungsun; ทัศนีย์ เต็งรังสรรค์; Theeralaksna Suddhasthira; ธีรลักษณ์ สุทธเสถียร; Kikuchi, Kiyoshi; Vechvongvan, Nuttavun; Tokuda, Masayuki; Maruyama, Ikuro; Mahidol University. Faculty of Dentistry. Department of Pharmacology; Mahidol University. Faculty of Dentistry. Department of Advanced General Dentistry; Mahidol University. Faculty of Dentistry. Department of PharmacologyHigh mobility group box 1 (HMGB1), a nonhistone DNA-binding protein, is released into the extracellular space and promotes inflammation. HMGB1 binds to related cell signaling transduction receptors, including receptor for advanced glycation end products (RAGE), which actively participate in vascular and inflammatory diseases. The aim of this study was to examine whether RAGE and HMGB1 are involved in the pathogenesis of pulpitis and investigate the effect of Prevotella intermedia (P. intermedia) lipopolysaccharide (LPS) on RAGE and HMGB1 expression in odontoblast-like cells (OLC-1). RAGE and HMGB1 expression levels in clinically inflamed dental pulp were higher than those in healthy dental pulp. Upregulated expression of RAGE was observed in odontoblasts, stromal pulp fibroblasts-like cells, and endothelial-like cell lining human pulpitis tissue. Strong cytoplasmic HMGB1 immunoreactivity was noted in odontoblasts, whereas nuclear HMGB1 immunoreactivity was seen in stromal pulp fibroblasts-like cells in human pulpitis tissue. LPS stimulated OLC-1 cells produced HMGB1 in a dose-dependent manner through RAGE. HMGB1 translocation towards the cytoplasm and secretion from OLC-1 in response to LPS was inhibited by TPCA-1, an inhibitor of NF-κB activation. These findings suggest that RAGE and HMGB1 play an important role in the pulpal immune response to oral bacterial infection.Publication Open Access Factors Predicting Depressive Symptoms among Older People in Community in Bali, Indonesia(2020) Made Dian Shanti Kusuma; Yajai Sitthimongkol; Virapun Wirojratana; Paungpet Kesornsamut; ยาใจ สิทธิมงคล; วิราพรรณ วิโรจน์รัตน์; พวงเพชร เกษรสมุทร; Mahidol University. Faculty of NursingPurpose: To examine the rate of depressive symptoms and factors predicting depressive symptoms among older people in community. Design: Correlational predictive study. Methods: The study is descriptive and cross-sectional. Simple random sampling was used to select 177 older people living in Bali, Indonesia. A cognitive assessment was carried out prior to selection. The instruments were self-reported Non-Communicable Diseases, behavioral risk questionnaires including smoking behavior, Body Mass Index, alcohol consumption, physical activity, adverse life events scale, and depression scale. Descriptive statistics and logistic regression were employed for statistical analysis. Main Findings: The findings revealed that approximately 42% of respondents had depressive symptoms. Adverse life events, having more than three Non-Communicable Diseases, and low physical activity were found as significant predictors of depressive symptoms (Odds Ratio = 1.30, 4.41, 4.60, p < .05, respectively). Gender, Body Mass Index, smoking, and alcohol consumption were not found to be significant predictors of depressive symptoms. Conclusion and recommendations: The findings support that the older people living in community are at risk of depression. Depressive symptoms could be predicted by adverse life events, non-communicable diseases and low physical activities. This research contributes to the community nurses on the promotion of physical activity to those older people with Non-Communicable Diseases and proposes interventions that permit improvements in their psychological health. Community nurses should develop an intervention aiming to prevent depression, through promotion of physical activity in accordance with physical ability, and enhancing coping skills.Publication Open Access Ethnoveterinary medicine based on Ayurveda plants(2012) Sookruetai Boonmasawai; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceTraditional plants used for medicine exist for several thousand years ago in India to solve human health problems. The Ayurveda concept involved in the balancing of five basic elements including earth, water, fire, air, and space (ether) because of various active ingredients in remedies. Nowadays, traditional plant uses in veterinary medicine in many regions have been documented and reported such as in Spain, Italy, Argentina, Brazil and Kenya. Catharanthus roseus (Apocynaceae) is an important medicinal plant containing vincristine used in veterinary medicine for treatment of canine transmissible venereal tumor and canine lymphoma. Additional evidences in China showed that Salacia oblonga root in Ayurvedic recipe was able to ameliorate hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. Moreover, crude extract from Terminalia arjuna L. (Combretaceae) bark decreased blood pressure in anaesthetized dogs. However, World Health Organization (WHO) recently focuses in standardization, safety and efficacy of Ayurveda medicine to establish this herbal medicine system. Ayurveda in veterinary medicine still need further clinical research to provide more clear, comprehensive, and practical pharmacological information to improve constantly therapeutic qualities.Publication Open Access Ethnoveterinary medicine based on Ayurveda plants(2012) Sookruetai Boonmasawai; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceTraditional plants used for medicine exist for several thousand years ago in India to solve human health problems. The Ayurveda concept involved in the balancing of five basic elements including earth, water, fire, air, and space (ether) because of various active ingredients in remedies. Nowadays, traditional plant uses in veterinary medicine in many regions have been documented and reported such as in Spain, Italy, Argentina, Brazil and Kenya. Catharanthus roseus (Apocynaceae) is an important medicinal plant containing vincristine used in veterinary medicine for treatment of canine transmissible venereal tumor and canine lymphoma. Additional evidences in China showed that Salacia oblonga root in Ayurvedic recipe was able to ameliorate hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. Moreover, crude extract from Terminalia arjuna L. (Combretaceae) bark decreased blood pressure in anaesthetized dogs. However, World Health Organization (WHO) recently focuses in standardization, safety and efficacy of Ayurveda medicine to establish this herbal medicine system. Ayurveda in veterinary medicine still need further clinical research to provide more clear, comprehensive, and practical pharmacological information to improve constantly therapeutic qualities.Publication Open Access Effect of dietary fish oil supplement on nutrients digestibility and egg yolk omega-3 fatty acids contents in Japanese Quails(2016) Kunaporn Homyog; Surasak Jittakhot; Samatchaya Pengdit; Mahidol University. Faculty of Veterinary ScienceThis study were investigated the effects of dietary fish oil supplement on digestibility of nutrients, fatty acid composition of egg yolk and quality of eggs in Japanese quails. Three hundred and twenty, ten weeks old female Japanese quails were randomly divided into 2 treatments, replicated 8 cages with 20 birds per cage. Dietary treatments; control diet and fish oil supplement diet (added 6% fish oil) were fed for 30 days. Samples of diets, feces and egg were daily collected from last 5 days. For proximate analysis of fish oil supplement DM, EE and ash of feed intake were lower than control diet (P<0.01). Moreover, the dietary fish oil supplement on macronutrients digestibility revealed DM, ME (P<0.05) and ash were significantly decrease (P<0.01) and also found negative effect on nitrogen metabolism (P<0.05). Fish oil supplement had significantly negative effect on egg production, egg weight and yolk width (P<0.05). However, detected the increasing of saturated fatty acids, unsaturated fatty acids, omega 3 and omega 9 fatty acids contents of quails fed fish oil supplement diet (P<0.01). On the other hand, fish oil supplement diets were highly significant decrease in omega 6 fatty acids and omega 6 to omega 3 fatty acid ratio (P<0.01). In summary, dietary fish oil supplemented can caused positive effect on content of saturated fatty acids, unsaturated fatty acids, omega 3 and omega 9 fatty acids, but had adverse effect either macro-nutrients intake or their digestibility. Additionally dietary fish oil supplemented lead to lower omega 6 to omega 3 ratios that cloud be beneficial effect on human health.Publication Open Access Discrepant association of serum C-3 epimer of 25-hydroxyvitamin D versus non-epimeric 25-hydroxyvitamin D with serum lipid levels(2016) La-or Chailurkit; Wichai Aekplakorn; Kriangsuk Srijaruskul; Boonsong Ongphiphadhanakul; Mahidol University. Ramathibodi Hospital. Department of MedicineBackground: Low vitamin D status has been associated with a number of chronic diseases. For dyslipidemia, vitamin D deficiency has been associated with higher low density lipoprotein-cholesterol (LDL-C) in a number of studies, but with inconsistent results in clinical trials. The purpose of the present study is to explore the relative importance of 3-epi-25-hydroxyvitamin D (25(OH)D) as compared with the non-epimeric form in relation to serum lipid. Method: This study used data from 1068 randomly selected volunteers in the Thai 4th National Health Examination Survey (NHES IV). Serum 25(OH)D2, 25(OH)D3, 3-epi-25(OH)D2 and 3-epi-25(OH)D3 were analyzed by liquid chromatography–tandem mass spectrometry. Results: There was no association between serum total 25(OH)D and serum LDL-C. However, circulating 3-epi-25(OH)D3 was negatively related to serum LDL-C (r = −0.077, P <0.05), while no such association was found for non-epimeric 25(OH)D3 (r =0.030, P = 0.33). On the other hand, both 3-epi-25(OH)D3 (r = 0.175, P <0.001) and non-epimeric 25(OH)D3 (r = 0.142, P <0.001) were positively related to serum triglyceride (TRIG) levels. In multiple linear regression models with age, gender, body mass index , urban residence, education, hypertension and education as covariates, it was found that 3-epi-25(OH)D3 was independently associated with serum LDL-C (beta = −0.12, P <0.01), while non-epimeric 25(OH)D3 was positively related to LDL-C (beta = 0.13, P = 0.002). For TRIG, there were positive association with 3-epi-25(OH)D3 (beta = 0.27, P <0.001) and negative association with non-epimeric 25(OH)D3 (beta = − 0.10, P = 0.011) independent of age, gender, urban resident and education. Conclusions: There is a discrepant association of 25(OH)D levels with serum lipids according to 25(OH)D epimeric forms.Publication Open Access Postmenopausal Osteoporosis in Relation to Toll-like Receptor-7 and HLA DQB1 Gene Expression on Peripheral Blood Mononuclear Cells(2016) Wanwisa Waiyaput; Mayuree Jirapinyo; Charnchai Suchartwattanachai; Boonsong Ongphiphadhanakul; Somphoch Pumipichet; Areepan Sophonsritsuk; วรรณวิสา ไวยพุฒ; มยุรี จิรภิญโญ; ชาญชัย สุชาติวัฒนชัย; บุญส่ง องค์พิพัฒนกุล; สมโภช ภูมิพิเชฐ; อารีย์พรรณ โสภณสฤษฎ์สุข; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Research, and Innovation; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Obstetrics and Gynecology; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of MedicineBackground: Data from genome wide association study have demonstrated that the toll-like receptor-7 gene (TLR7), a well-known role in innate immunity, may participate in the development of postmenopausal osteoporosis. The HLA DQB1 gene is part of human leukocyte antigen (HLA) complex. HLA DQB1 plays a critical role in the immune system. Objective: To determine the association of postmenopausal osteoporosis and transcripts of TLR7 and HLA DQB1 from peripheral blood mononuclear cells (PBMCs). Methods: The study groups included 25 postmenopausal women with normal bone mineral density (BMD) and the other 25 women with osteoporosis. Blood was drawn from the subjects for bone markers and PBMCs preparation. RNA was then isolated and quantitative RT-PCR was performed for TLR7 and HLA DQB1 genes. Results: PBMCs expression of both TLR7 and HLA DQB1 were not significantly different between postmenopausal women with normal BMD and those with osteoporosis. (P = 0.567 and P = 0.248, respectively). Conclusions: It is unlikely that TLR7 and HLA DQB1 contribute a major role on postmenopausal osteoporosis in Thai women.