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    ItemOpen Access
    In vitro activity of biapenem and comparators against multidrug-resistant and carbapenem-resistant Acinetobacter baumannii isolated from tertiary care hospitals in Thailand
    (2019) Jantana Houngsaitong; Preecha Montakantikul; Taniya Paiboonwong; Mullika T Chomnawang; Piyatip Khuntayaporn; Suvatna Chulavatnatol; จันทนา ห่วงสายทอง; ปรีชา มนทกานติกุล; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Pharmacy. Department of Microbiology
    Acinetobacter baumannii is one of nosocomial pathogen which emerge as multidrugresistance worldwide. Multidrug-resistant A. baumannii (MDRAB) and carbapenem-resistant A. baumannii (CRAB) are highly concerned due to limitation of therapeutic... options. Antibacterial activity of biapenem was explored in order to overcome bacterial resistance. Total of 412 A. baumannii clinical isolates from 13 tertiary care hospitals in Thailand were collected. MIC values of biapenem and comparators; imipenem
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    PublicationOpen Access
    Aedesin: structure and antimicrobial activity against multidrug resistant bacterial strains.
    (2014-08-27) Godreuil, Sylvain; Leban, Nadia; Padilla, Andre´; Hamel, Rodolphe; Natthanej Luplertlop; นัฏฐเนศวร์ ลับเลิศลบ; Chauffour, Aure´ lie; Vittecoq, Marion; Hoh, Franc¸ois; Thomas, Fre´de´ ric; Sougakoff, Wladimir; Lionne, Corinne; Yssel, Hans; Misse, Dorothe´e; Misse, Dorothe´e; Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology.
    Multidrug resistance, which is acquired by both Gram-positive and Gram-negative bacteria, causes infections that are associated with significant morbidity and mortality in many clinical settings around the world. Because of the rapidly increasing... effects against a large panel of multidrug resistant bacterial strains, directly isolated from infected patients. Based the results from nuclear magnetic resonance spectroscopy analysis, Aedesin has a helix-bend-helix structure typical for a member
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    PublicationOpen Access
    Efficacy of cinnamon bark oil and cinnamaldehyde on anti-multidrug resistant Pseudomonas aeruginosa and the synergistic effects in combination with other antimicrobial agents
    (2016) Itsaraporn Utchariyakiat; Suvimol Surassmo; Montree Jaturanpinyo; Piyatip Khuntayaporn; Mullika Traidej Chomnawang; Mahidol University. Faculty of Pharmacy. Department of Microbiology
    of essential oils were examined for anti-multidrug resistant P. aeruginosa (MDR-PA) activity, of which cinnamon bark oil showed the strongest antimicrobial activity against all clinical-isolated MDR-PA strains with MIC of 0.0562–0.225 % v/v and MBC of 0... demonstrated synergistic rates at 16.7 and 10 %, respectively. Conclusion: These results indicated that cinnamon bark oil and cinnamaldehyde might be active natural compounds which could be further examined as alternative treatment for multidrug-resistant P
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    PublicationOpen Access
    CD2068 potentially mediates multidrug efflux in Clostridium difficile
    (2017) Chawalit Ngernsombat; Suthasinee Sreesai; Phurt Harnvoravongchai; Surang Chankhamhaengdecha; Tavan Janvilisri; Mahidol University. Faculty of Science. Department of Biochemistry; Mahidol University. Faculty of Science. Department of Biology
    Clostridium difficile is a major cause of antibiotic-associated diarrhea and the treatment thereof becomes more difficult owing to a rise of multidrug resistant strains. ATP-binding cassette (ABC) transporters are known to play a crucial role... in the resistance to multiple antibiotics. In this study, the potential contribution of an ABC transporter in C. difficile multidrug resistance was investigated. The expression level of the cd2068 gene in C. difficile encoding an ABC transporter was up-regulated
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    PublicationOpen Access
    Adherence of Healthcare Workers Toward the Contact Precaution Guidelines for Patients With Multidrug-Resistant Organisms in a Tertiary Care Hospital
    (2018) Mukkapon Punpop; Porntip Malathum; Kumthorn Malathum; มุขพล ปุนภพ; พรทิพย์ มาลาธรรม; กำธร มาลาธรรม; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Ramathibodi School of Nursing; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Medicine
    Background: The medical intermediate care unit (MIU) is an open ward had the highest prevalence of multidrug-resistant organisms (MDROs) in Ramathibodi Hospital. Until now, contact precautions have been used to control the MDROs in this unit
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    PublicationOpen Access
    Prevalence and genotypic relatedness of carbapenem resistance among multidrug-resistant P. aeruginosa in tertiary hospitals across Thailand
    (2012) Piyatip Khuntayaporn; Preecha Montakantikul; Piroon Mootsikapun; Visanu Thamlikitkul; Mullika Traidej Chomnawang; Mahidol University. Faculty of Pharmacy. Department of Microbiology; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Khon Kaen University. Faculty of Medicine. Department of Medicine; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Medicine
    Background: Increased infection caused by multidrug resistant (MDR) Pseudomonas aeruginosa has raised awareness of the resistance situation worldwide. Carbapenem resistance among MDR (CR-MDR) P. aeruginosa has become a serious life-threatening... that the meropenem resistance rate was the highest reaching over 50% in every hospitals. Additionally, the type of hospitals was a major factor affecting the resistance rate, as demonstrated by significantly higher CR-MDR rates among university and regional
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    PublicationOpen Access
    Measuring ex vivo drug susceptibility in Plasmodium vivax isolates from Cambodia
    (2017) Suwanna Chaorattanakawee; Chanthap Lon; Soklyda Chann; Kheang Heng Thay; Nareth Kong; You, Yom; Siratchana Sundrakes; Chatchadaporn Thamnurak; Sorayut Chattrakarn; Chantida Praditpol; Kritsanai Yingyuen; Wojnarsk, Mariusz i; Huy, Rekol; Spring, Michele D.; Walsh, Douglas S.; Patel, Jaymin C.; Lin, Jessica; Juliano, Jonathan J.; Lanteri, Charlotte A.; Saunders, David L.; Mahidol University. Faculty of Public Health
    Background: While intensive Plasmodium falciparum multidrug resistance surveillance continues in Cambodia, relatively little is known about Plasmodium vivax drug resistance in Cambodia or elsewhere. To investigate P. vivax antimalarial... dehydrogenase (pLDH) ELISA. P. vivax multidrug resistance gene 1 (pvmdr1) mutations, and copy number were analysed in a subset of isolates. Results: Ex vivo testing was interpretable in 80% of isolates using the pLDH-ELISA, but only 25% with the SMT
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    PublicationOpen Access
    Classification of P-glycoprotein-interacting compounds using machine-learning methods
    (2015-07) Watshara Shoombuatong; Apilak Worachartcheewan; Veda Prachayasittikul; Chanin Nantasenamat; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical Informatics
    P-glycoprotein (Pgp) is a drug transporter that plays important roles in multidrug resistance and drug pharmacokinetics. The inhibition of Pgp has become a notable strategy for combating multidrug-resistant cancers and improving therapeutic outcomes
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    PublicationOpen Access
    P-Glycoprotein transporter in drug development
    (2016-02-12) Veda Prachayasittikul; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology
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    PublicationOpen Access
    Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape.
    (2014-06-10) Croucher, Nicholas J.; Chewapreecha, Claire; Hanage, William P.; Harris, Simon R.; McGee, Lesley; Linde, Mark van der; Song, Jae-Hoon; Ko, Kwan Soo; Lencastre, Herminia de; Turner, Claudia; Yang, Fan; Sa´ -Lea˜o, Raquel; Beall, Bernard; Klugman, Keith P.; Parkhill, Julian; Turner, Paul; Bentley, Stephen D.; Bentley, Stephen D.; Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit.
    The multidrug-resistant Streptococcus pneumoniae Taiwan(19F)-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, "vaccine escape" PMEN14 isolates... that originated in the late 1980s in parallel with the acquisition of multiple resistances by close relatives. One of the four detected serotype switches to 19A generated representatives of the sequence type (ST) 320 isolates that have been highly successful