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Publication Open Access Antiosteoporotic effect of sequential extracts and freezedried juice of Cissus quadrangularis L. in ovariectomized mice(2012) Thanika Pathomwichaiwat; Wisuda Suvitayavat; Achariya Sailasuta; Pawinee Piyachaturawat; Noppamas Soonthornchareonnon; Sompop Prathanturarug; Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical Botany; Mahidol University. Faculty of Pharmacy. Department of Physiology; Mahidol University. Faculty of Pharmacy. Department of Pharmacognosy; Mahidol University. Faculty of Science. Department of Physiologyany toxicity throughout the experiment. Therefore, the hexane extract is the most interesting for further bioassay-guided purification of pharmacologically active compounds.... on bone metabolism; however, there has been no investigation to identify the active compounds responsible for this activity. Objective: Sequential extracts (hexane, dichloromethane, ethanol, and water) and freeze-dried CQ juice were investigatedPublication Open Access Effects of alcoholic extract from pomegranate (Punica granatum L.) peels on gastrointestinal nematode egg counts in doe(2013) Sookruetai Boonmasawai; Sivapong Sungpradit; Charoonluk Jirapattharasate; Chowalit Nakthong; Lak Piasai; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal Science; Mahidol University. Faculty of Veterinay Science. Department of Clinical Sciences and Public Healthactivity of alcoholic extract from pomegranate peels against female goat gastrointestinal nematodes and the toxic effects after treatments. The results were shown that albendazole and pomegranate peel powder could not affect percent of strongyle egg per... requiring, especially using local economic plants or remedies for reducing the impact. The pomegranate (Punica granatum L.) is one kind of fruit that is used as an anthelmintic plant in Ayurveda remedies for a long time. We investigated the anthelminticPublication Open Access Biological and phytochemical studies of Millettia brandisiana(2005-06) Tippawan Vongthongsri; Komgrit Manyam; Chayut Thanapirom; Metaneeya Pilanthananond; Chanpen Wiwat; Noppamas Soonthornchareonnon; Mahidol University. Faculty of PharmacyThe ethanolic and water extracts from twigs, leaves and fruits of Millettia brandisiana Kurz were investigated. It is interesting to note that all of the extracts exhibited inactive against gram negative bacteria. The water extract of twigs showed... the most active anti-gram positive bacteria at the concentration of 5.0 mg/disc. The crude water extract of twig showed the most active in the DPPH radical scavenging assay with IC50 values of 2.34 μg/ml which more active than the standard antioxidantsPublication Open Access Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn(2015-03) Rungrot Cherdtrakulkiat; Somchai Boonpangrak; Somsak Ruchirawat; Ratchanok Pingaew; Virapong Prachayasittikul; Supaluk Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology; Mahidol University. Faculty of Medical Technology. Center for Innovation Development and Technology Transfer; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical InformaticsBioactive triterpenoids; 3-acetylaleuritolic acid, stigmasterol, a mixture of triterpenoids, fatty esters and aromatic components were isolated from the aerial parts of Eclipta prostrata by column chromatography. The plant extracts were investigated... displayed antioxidant effect. In addition, the plant extracts showed cytotoxic activity (ED50 > 100 g/mL) toward HuCCA-1 and KB cells. The results demonstrate beneficial effects of E. prostrata as the antimicrobials and bioactive compounds for medicinalPublication Open Access Cytotoxicity evaluation of Clinacanthus nutans through dimethylthiazol diphenyltetrazolium bromide and neutral red uptake assays.(2016-01) Suwanna Korsuwannawong; สุวรรณา ก่อสุวรรณวงศ์; La‑Ongthong Vajrabhaya; ละอองทอง วัชราภัย; Suwanna Korsuwannawong; Mahidol University. Faculty of Dentistry. Research OfficeObjectives: The aim of this study was to compare the results of dimethylthiazol diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) assays of Clinacanthus nutans cytotoxicity. Materials and Methods: Mouse fibroblast (L929) cells were exposed to 0.01%, 0.1%, 0.25%, and 0.5% (W/V) C. nutans in a 96-cluster -well-culture plate for 24 h. The cell viability after exposure to C. nutans was determined by MTT and NRU assays in separate tissue culture plates. The two assays were compared through an intra‑class correlation coefficient (ICC) analysis. Results: No significant differences in cytotoxicity were noted between the two assays ( P > 0.05). The ICC values for agreement between two assays for the negative and positive control groups and C. nutans concentrations of 0.01%, 0.1%, 0.25%, and 0.5% were 0.84, 0.83, 0.77, 0.68, 0.74, and 0.71, respectively. Conclusion: In general, the MTT and NRU assays performed similarly, exhibiting moderate to good correlation for the evaluation of the cytotoxicity of C. nutans .Publication Open Access Soil physicochemical status and nutrient management for paddy soils in the lower central plain of Thailand after the flood disaster in 2011(2014-06) Benjaporn Intorpetch; Worachart Wisawapipat; Chumlong Arunlertaree; Piyakarn Teartisup; Mahidol University. Faculty of Environment and Natural Resource Studies. Liming should also be used to minimize potential Al/metals toxicity and correct imbalances of plant nutrients. Several plant nutrients (NPK) and organic materials need to be regularly applied to maintain soil fertility levels at optimum values.Publication Open Access Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury(2017) Sirintorn Srimachai; Devaux, Sylvie; Demougeot, Celine; Sarawut Kumphune; Ullrich, Nina D.; Niggli, Ernst; Kornkanok Ingkaninan; Natakorn Kamkaew; Scholfield, Norman; Sompol Tapechum; Krongkarn Chootip; Mahidol University. Faculty of Medicine, Siriraj Hospital, Department of Physiology; Naresuan University. Faculty of Medical Science. Department of Physiology; Naresuan University. Faculty of Allied Health Sciences. Department of Medical Technology; Naresuan University. Faculty of Pharmaceutical Sciences. Department of Pharmaceutical Chemistry and Pharmacognosy; University of Phayao. School of Medical Sciences; Heidelberg University. Department of Physiology and Pathophysiologyextract (30 min), or (ii) with normal solution or extract for 10 min preceding no-perfusion ischemia (30 min) followed by reperfusion (30 min) with normal solution. Infarct volumes were measured by triphenyltetrazolium staining. L-type Ca2+-currents (ICaPublication Open Access Chronic Ingestion of High Dosed Phikud Navakot Extraction Induces Mesangiolysis in Rats with Alteration of AQP1 and Hsp60 Expressions(2015-02-10) Kanchana Kengkoom; Sumate Ampawong; Mahidol University. National Laboratory Animal Centre; Mahidol University. Faculty of Tropical MedicinePhikud Navakot (PN) is commonly used in Thai traditional medicine for alleviation 18 of cardiovascular and cerebrovascular symptoms, however little is known about the 19 chronic toxicity effects of the extracts from the herbs in PN. Repeated... extraction doses of 20 10, 100, and 1,000 mg/kg/day were randomly administered to both male and female 21 Sprague Dawley rats for 12 months. Histopathological study revealed that mesangiolysis 22 was predominately found at the highest dose. Aquaporin 1 (AQP1Publication Open Access Spatial distribution of potentially toxic trace elements of agricultural soils in the lower central plain of Thailand after the 2011 flood(2014-06) Aksarapak Pongpom; Kampanad Bhaktikul; Worachart Wisawapipat; Piyakarn Teartisup; Kampanad Bhaktikul; Mahidol University. Faculty of Environment and Natural Resource StudiesPublication Open Access Anthelminthic effects of artemisinin and its derivatives(2013) Tawewan Tansatit; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal ScienceQinghao (Artemisia annua, L.), a famous herb from China, has been used in traditional Chinese medicine. Artemisinin, an active substance is extracted from the leaves and flowers of Qinghao, with a unique sesquiterpene lactone endoperoxide structure... promising possibility for clinical utility in anthelmintic application. Toxicity of artemisinin derivatives was less and was demonstrated in experimental animals with neurotoxicity and anemia.
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