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Publication Open Access Factors related to dental nurse preparation for working in Tambon Health Promoting Hospitals in Thailand(2016) Somrit Jirojvanichakorn; Nate Hongkrailert; Jiraporn Chompikul; Boonyong Keiwkarnka; Mahidol University. ASEAN Institute for Health Developmentother chief of a dental department of a community hospital, hospital policy, hospital assignment, hospital budget support and hospital manpower management system. The most significant predictors was hospital assignments (Adj. OR=2.87, 95%CI=1.76-4....65). Chiefs who had hospital assignments were 2.87 times more likely to be well prepared than those who had not after adjusting for other factors. The research recommendation showed that the department chiefs need to be encouraged to achieve better dentalPublication Open Access Development of a verbal autopsy tool for investigating cause of death: the Kanchanaburi project(2007-01) Pramote Prasartkul; ปราโมทย์ ประสาทกุล; Yawarat Porapakham; Patama Vapattanawong; ปัทมา ว่าพัฒนวงศ์; Jongjit Rittirong; จงจิตต์ ฤทธิรงค์; Boonlert Leoprapai; Mahidol University. Institute for Population and Social ResearchThe study described the development of a verbal autopsy (VA) tool, in which a relative or caretaker of a descendent was interviewed about symptoms or events preceding the death, to identify the underlying cause of death (COD). The tool applied in this study transforms detailed VA questionnaires via an algorithm into a probable COD. To test the validity of the tool, preliminary matching was carried out between COD from two independent sources, from expert review of hospital records and from the VA tool algorithm. Validity testing was carried out in 2003 by examining 921 cases of hospital deaths in Kanchanaburi province occurring in 2002. After excluding VA interview non-response and insufficient medical record cases, 652 COD cases were compared. The test indicated a tolerable degree of validity and suggested revisions that helped to improve the questionnaire. The revised version has been coded as a computer program to substitute for the voluminous paper questionnaire in hand-held computers for convenient use.Publication Open Access A single multilocus sequence typing (MLST) scheme for seven pathogenic Leptospira species(2013) Siriphan Boonsilp; ศิริพรรณ บุญศิลป์; Janjira Thaipadungpanit; จันทรจิรา ไทยผดุงพานิช; Premjit Amornchai; เปรมจิตร อมรชัย; Vanaporn Wuthiekanun; วรรณพร วุฒิเอกอนันต์; Bailey, Mark S.; Holden, Matthew T. G.; Zhang, Cuicai; Jiang, Xiugao; Koizumi, Nobuo; Taylor, Kyle; Galloway, Renee; Hoffmaster, Alex R.; Craig, Scott; Smythe, Lee D.; Hartskeerl, Rudy A.; Day, Nicholas P.; Narisara Chantratita; นริศรา จันทราทิตย์; Feil, Edward J.; Aanensen, David M.; Spratt, Brian G.; Peacock, Sharon J.; Janjira Thaipadungpanit; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit; Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunologydiscrete clade, and that no strains were misclassified at the species level. Comparison between genotype and serovar was possible for 254 isolates. Of the 31 sequence types (STs) represented by at least two isolates, 18 STs included isolates assigned... between human disease and specific maintenance hosts was demonstrated. CONCLUSION: The new MLST scheme, supported by an updated MLST website, allows the characterization and species assignment of isolates of the seven major pathogenic speciesPublication Open Access Efficacy of a church-based lifestyle intervention programme to control high normal blood pressure and/or high normal blood glucose in church members: a randomized controlled trial in Pretoria, South Africa(2014) Supa Pengpid; Peltzer, Karl; Skaal, Linda; Hendry Van der Heever; Mahidol University. ASEAN Institute for Health Developmentgroup during 6, 12, 24 and 36 months during and post intervention. The study will use a group-randomized design, recruiting 300 church members from 12 churches. Churches will be randomly assigned to experimental and control conditions. DiscussionPublication Open Access Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial(2014) Jones, Deborah; Peltzer, Karl; Weiss, Stephen M; Sifunda, Sibusiso; Dwane, Ntabozuko; Ramlagan, Shandir; Cook, Ryan; Matseke, Gladys; Maduna, Vincent; Spence, Andrew; Mahidol University. ASEAN Institute for Health Development: The study follows a cluster randomized controlled design enrolling two cohorts of HIV-positive pregnant women recruited from 12 randomly assigned Community Health Centers (CHC) (six experimental, six control). The two cohorts will consist of womenPublication Open Access The impact of different GFR estimating equations on the prevalence of CKD and risk groups in a Southeast Asian cohort using the new KDIGO guidelines(2012) Chagriya Kitiyakara; Sukit Yamwong; Prin Vathesatogkit; Anchalee Chittamma; Sayan Cheepudomwit; Somlak Vanavanan; Bunlue Hengprasith; Piyamitr Sritara; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of MedicineBackground: Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) group recommended that patients with CKD should be assigned to stages and composite relative risk groups according to GFR (G) and proteinuria (A) criteria. Asians have.... CKD3-5 prevalence with S-MDRD and CKD-EPI were 2 - 3 folds higher than T-GFR or C-MDRD. The concordance with CKD-EPI to diagnose CKD3-5 was over 90% for T-GFR or C-MDRD, but they only assigned the same CKD stage in 50% of the time. The choicePublication Open Access Dental students’ reflections on their fieldwork experiences.(2015-09) Tippanart Vichayanrat; ทิพนาถ วิชญาณรัตน์; Nicha Luksamijarulkul; ณิชา ลักษมีจรัลกุล; Piyada Gaewkhiew; ปิยดา แก้วเขียว; Tippanart Vichayanrat; ทิพนาถ วิชญาณรัตน์; Mahidol University. Faculty of Dentistry. Department of Community Dentistryand sixth-year dental students were assigned to submit a written reflection after their 2-week and 4-week fieldwork experience. The fieldworks were organized every year in Nakhon Ratchasima province for 5th-year students, and five provinces in NorthernPublication Open Access Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial(2017) Wanwisa Waiyaput; Somphoch Pumipichet; Sawaek Weerakiet; Sasivimol Rattanasiri; Areepan Sophonsritsuk; Mahidol University. Department of Obstetrics & Gynecology, Ramathibodi Hospital . Reproductive Endocrinology and Infertility Unitwith endometriosis were recruited and randomly assigned to either a treatment group (20 mg/d of orally administered simvastatin for 2 weeks before surgery) or an untreated control group. Serum was collected before and after treatment and protein levels of MCP-1Publication Open Access ประสิทธิภาพของขนแปรงสีฟันเรียวเล็กและบิดเกลียวหมุนในการกำจัดคราบจุลินทรีย์(2013-09) กัลยรัตน์ ไกรประยูร; Kanyarat Kraiprayoon; ศิิรประภา ตันติกัลชาญ; Siraprapa Tantikalchan; สุชาวดี บุญยะวนิช; Suchawadee Boonyawanit; อรวิภา จาละ; Orawipa Jala; ยสวิมล คูผาสุข; Yosvimol Kuphasuk; วรุณี เกิดวงศ์บัณฑิต; Varunee Kerdvongbundit; วรุณี เกิดวงศ์บัณฑิต; Varunee Kerdvongbundit; มหาวิทยาลัยมหิดล. คณะทันตแพทยศาสตร์. ภาควิชาเวชศาสตร์ช่องปากและปริทันตวิทยา, crossover clinical study. Scaling and polishing were performed on all volunteers before each assignment. The teeth and gingiva were disclosed using erythrosine and Mira-2-Ton® disclosing solution, respectively. Pre- and post-brushing plaque score... and gingival abrasion were recorded after 24 hours overnight plaque accumulation. Subjects used their randomly assigned toothbrush for 3 minutes with modified Bass technique but was unaided by access to a mirror during brushing. After 2 weeks upon completionPublication Open Access Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.(2011) Campino, Susana; Auburn, Sarah; Kivinen, Katja; Zongo, Issaka; Ouedraogo, Jean-Bosco; Mangano, Valentina; Djimde, Abdoulaye; Doumbo, Ogobara K.; Kiara, Steven M.; Nzila, Alexis; Borrmann, Steffen; Marsh, Kevin; Michon, Pascal; Mueller, Ivo; Siba, Peter; Jiang, Hongying; Su, Xin-Zhuan; Chanaki Amaratunga; Socheat, Duong; Fairhurst, Rick M.; Mallika Imwong; มัลลิกา อิ่มวงศ์; Anderson, Timothy; Nosten, Francois; White, Nicholas J.; Gwilliam, Rhian; Deloukas, Panos; MacInnis, Bronwyn; Newbold, Christopher I.; Rockett, Kirk; Clark, Taane G.; Kwiatkowski, Dominic P.; Campino, Susana; Fitzgerald, J. Ross; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford University Research Unit.; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.The diversity in the Plasmodium falciparum genome can be used to explore parasite population dynamics, with practical applications to malaria control. The ability to identify the geographic origin and trace the migratory patterns of parasites with clinically important phenotypes such as drug resistance is particularly relevant. With increasing single-nucleotide polymorphism (SNP) discovery from ongoing Plasmodium genome sequencing projects, a demand for high SNP and sample throughput genotyping platforms for large-scale population genetic studies is required. Low parasitaemias and multiple clone infections present a number of challenges to genotyping P. falciparum. We addressed some of these issues using a custom 384-SNP Illumina GoldenGate assay on P. falciparum DNA from laboratory clones (long-term cultured adapted parasite clones), short-term cultured parasite isolates and clinical (non-cultured isolates) samples from East and West Africa, Southeast Asia and Oceania. Eighty percent of the SNPs (n = 306) produced reliable genotype calls on samples containing as little as 2 ng of total genomic DNA and on whole genome amplified DNA. Analysis of artificial mixtures of laboratory clones demonstrated high genotype calling specificity and moderate sensitivity to call minor frequency alleles. Clear resolution of geographically distinct populations was demonstrated using Principal Components Analysis (PCA), and global patterns of population genetic diversity were consistent with previous reports. These results validate the utility of the platform in performing population genetic studies of P. falciparum.