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Item Metadata only Anticancer effect of herbal and marine products: A systematic review(2023-11-01) Mizanur Rahaman M.; Wilairatana P.; Hasan Bappi M.; Islam T.; Nayem Mia M.; Douglas Melo Coutinho H.; Siyadatpanah A.; Torequl Islam M.; Mahidol UniversityThe majority of the world's nations have faced the second-highest cancer mortality rate. The main causes of cancer include an unbalanced diet, genetic factors, and a few specific environmental substances. Recently, a variety of substances have been used to treat cancer, and some are still being studied. It has long been known that the mid of the twentieth century that plant and marine species create a wide range of chemically and physiologically diverse metabolites with a variety of biological effects, including anticancer, anti-inflammatory, antioxidant, antibacterial, antifouling and so on. The focus of this study is on newly found compounds from plant and marine sources that have potent anticancer effects.Item Metadata only Alkaloids as drug leads in Alzheimer's treatment: Mechanistic and therapeutic insights(2024-07-01) Rezaul Islam M.; Akash S.; Murshedul Islam M.; Sarkar N.; Kumer A.; Chakraborty S.; Dhama K.; Ahmed Al-Shaeri M.; Anwar Y.; Wilairatana P.; Rauf A.; Halawani I.F.; Alzahrani F.M.; Khan H.; Rezaul Islam M.; Mahidol UniversityAlzheimer's disease (AD) has few effective treatment options and continues to be a major global health concern. AD is a neurodegenerative disease that typically affects elderly people. Alkaloids have potential sources for novel drug discovery due to their diverse chemical structures and pharmacological activities. Alkaloids, natural products with heterocyclic nitrogen-containing structures, are considered potential treatments for AD. This review explores the neuroprotective properties of alkaloids in AD, focusing on their ability to regulate pathways such as amyloid-beta aggregation, oxidative stress, synaptic dysfunction, tau hyperphosphorylation, and neuroinflammation. The FDA has approved alkaloids such as acetylcholinesterase inhibitors like galantamine and rivastigmine. This article explores AD's origins, current market medications, and clinical applications of alkaloids in AD therapy. This review explores the development of alkaloid-based drugs for AD, focusing on pharmacokinetics, blood–brain barrier penetration, and potential adverse effects. Future research should focus on the clinical evaluation of promising alkaloids, developing recently discovered alkaloids, and the ongoing search for novel alkaloids for medical treatment. A pharmaceutical option containing an alkaloid may potentially slow down the progression of AD while enhancing its symptoms. This review highlights the potential of alkaloids as valuable drug leads in treating AD, providing a comprehensive understanding of their mechanisms of action and therapeutic implications.Item Metadata only Retraction notice to "Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance"(Biomedicine & Pharmacotherapy, (2022), 153, C, (113305), (S0753332222006941), 10.1016/j.biopha.2022.113305)(2026-01-01) Rahman M.M.; Islam M.R.; Akash S.; Harun-Or-Rashid M.; Ray T.K.; Rahaman M.S.; Islam M.; Anika F.; Hosain M.K.; Aovi F.I.; Hemeg H.A.; Rauf A.; Wilairatana P.; Rahman M.M.; Mahidol UniversityThis article has been retracted: please see Elsevier Policy on Article Correction, Retraction and Removal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editor. Post-publication, an investigation conducted by Elsevier's Research Integrity & Publishing Ethics team on behalf of the journal identified references that are irrelevant to the article. The authors were asked to comment upon the presence of these references in their work but were unable to satisfactorily address the reason for the references. Consequently, the editor has lost confidence in the results and conclusions of the article and has determined it should be retracted. Apologies are offered to readers of the journal that this was not detected during the submission process. The authors disagree with retraction and dispute the grounds for itItem Metadata only Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer's Disease(2022-01-01) Islam F.; Khadija J.F.; Harun-Or-Rashid M.; Rahaman M.S.; Nafady M.H.; Islam M.R.; Akter A.; Emran T.B.; Wilairatana P.; Mubarak M.S.; Mahidol UniversityAlzheimer's disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. AD is still the most prevalent form of dementia and affects many individuals across the globe. The exact cause of the disorder is obscure. There are yet no effective medications for halting, preventing, or curing AD's progress. Plenty of natural products are isolated from several sources and analyzed in preclinical and clinical settings for neuroprotective effects in preventing and treating AD. In addition, natural products and their derivatives have been promising in treating and preventing AD. Natural bioactive compounds play an active modulatory role in the pathological molecular mechanisms of AD development. This review focuses on natural products from plant sources and their derivatives that have demonstrated neuroprotective activities and maybe promising to treat and prevent AD. In addition, this article summarizes the literature pertaining to natural products as agents in the treatment of AD. Rapid metabolism, nonspecific targeting, low solubility, lack of BBB permeability, and limited bioavailability are shortcomings of most bioactive molecules in treating AD. We can use nanotechnology and nanocarriers based on different types of approaches.Item Metadata only Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance(2022-09-01) Rahman M.M.; Islam M.R.; Akash S.; Harun-Or-Rashid M.; Ray T.K.; Rahaman M.S.; Islam M.; Anika F.; Hosain M.K.; Aovi F.I.; Hemeg H.A.; Rauf A.; Wilairatana P.; Mahidol UniversityNanoscale engineering is one of the innovative approaches to heal multitudes of ailments, such as varieties of malignancies, neurological problems, and infectious illnesses. Therapeutics for neurodegenerative diseases (NDs) may be modified in aspect because of their ability to stimulate physiological response while limiting negative consequences by interfacing and activating possible targets. Nanomaterials have been extensively studied and employed for cancerous therapeutic strategies since nanomaterials potentially play a significant role in medical transportation. When compared to conventional drug delivery, nanocarriers drug delivery offers various benefits, such as excellent reliability, bioactivity, improved penetration and retention impact, as well as precise targeting and administering. Upregulation of drug efflux transporters, dysfunctional apoptotic mechanisms, and a hypoxic atmosphere are all elements that lead to cancer treatment sensitivity in humans. It has been possible to target these pathways using nanoparticles and increase the effectiveness of multidrug resistance treatments. As innovative strategies of tumor chemoresistance are uncovered, nanomaterials are being developed to target specific pathways of tumor resilience. Scientists have recently begun investigating the function of nanoparticles in immunotherapy, a field that is becoming increasingly useful in the care of malignancies. Nanoscale therapeutics have been explored in this scientific literature and represent the most current approaches to neurodegenerative illnesses and cancer therapy. In addition, current findings and various biomedical nanomaterials' future promise for tissue regeneration, prospective medication design, and the synthesis of novel delivery approaches have been emphasized.Item Metadata only Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review(2023-08-19) Bhuia M.S.; Wilairatana P.; Ferdous J.; Chowdhury R.; Bappi M.H.; Rahman M.A.; Mubarak M.S.; Islam M.T.; Mahidol UniversityFruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in various Uncaria species and has a multitude of therapeutic benefits. It is found in foodstuffs such as fish, seafood, meat, poultry, dairy, and some grain products among other things. In addition, it is present in fruits and vegetables including corn, cauliflower, mushrooms, potatoes, bamboo shoots, bananas, cantaloupe, and citrus fruits. The primary emphasis of this study is to summarize the pharmacological activities and the underlying mechanisms of HSN against different diseases, as well as the biopharmaceutical features. For this, data were collected (up to date as of 1 July 2023) from various reliable and authentic literature by searching different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. Findings indicated that HSN exerts several effects in various preclinical and pharmacological experimental systems. It exhibits anti-inflammatory, antiviral, anti-diabetic, and antioxidant activities with beneficial effects in neurological and cardiovascular diseases. Our findings also indicate that HSN exerts promising anticancer potentials via several molecular mechanisms, including apoptotic cell death, induction of oxidative stress, cytotoxic effect, anti-proliferative effect, genotoxic effect, and inhibition of cancer cell migration and invasion against various cancers such as lung, breast, and antitumor effects in human T-cell leukemia. Taken all together, findings from this study show that HSN can be a promising therapeutic agent to treat various diseases including cancer.Item Metadata only Anticancer Potentials of the Lignan Magnolin: A Systematic Review(2023-05-01) Bhuia M.S.; Wilairatana P.; Chowdhury R.; Rakib A.I.; Kamli H.; Shaikh A.; Coutinho H.D.M.; Islam M.T.; Mahidol UniversityMagnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was conducted using various academic search engines, including PubMed, Springer Link, Wiley Online, Web of Science, Science Direct, and Google Scholar. All the currently available information about this phytochemical and its role in various cancer types has been gathered and investigated. Magnolin is a compound found in many different plants. It has been demonstrated to have anticancer activity in numerous experimental models by inhibiting the cell cycle (G1 and G2/M phase); inducing apoptosis; and causing antiinvasion, antimetastasis, and antiproliferative effects via the modulation of several pathways. In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.Item Metadata only Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives(2024-01-01) Islam M.R.; Rauf A.; Akash S.; Trisha S.I.; Nasim A.H.; Akter M.; Dhar P.S.; Ogaly H.A.; Hemeg H.A.; Wilairatana P.; Thiruvengadam M.; Islam M.R.; Mahidol UniversityThe curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with curcumin in a complex. When combined with other enhancing agents, curcumin has a wide spectrum of health benefits. This review evaluates the therapeutic potential of curcumin with a specific emphasis on its approach based on molecular signaling pathways. This study investigated its influence on the progression of cancer, inflammation, and many health-related mechanisms, such as cell proliferation, apoptosis, and metastasis. Curcumin has a significant potential for the prevention and treatment of various diseases. Curcumin modulates several biochemical pathways and targets involved in cancer growth. Despite its limited tissue accumulation and bioavailability when administered orally, curcumin has proven useful. This review provides an in-depth analysis of curcumin's therapeutic applications, its molecular signaling pathway-based approach, and its potential for precision medicine in cancer and human health.Item Metadata only Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action(2022-05-01) Mitra S.; Anjum J.; Muni M.; Das R.; Rauf A.; Islam F.; Bin Emran T.; Semwal P.; Hemeg H.A.; Alhumaydhi F.A.; Wilairatana P.; Mahidol UniversityEmodin is an anthraquinone derivative found in the roots and bark of a variety of plants, molds, and lichens. Emodin has been used as a traditional medication for more than 2000 years and is still common in numerous herbal drugs. Emodin is plentiful in the three plant families, including Polygonaceae (Rheum, Rumex, and Polygonum spp.), Fabaceae (Cassia spp.), and Rhamnaceae (Rhamnus, Frangula, and Ventilago spp.). Emerging experimental evidences indicate that emodin confers a wide range of pharmacological activities; special focus was implemented toward neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, anxiety and depression, schizophrenia, chronic hyperglycemic peripheral neuropathy, etc. Numerous preclinical evidences were established in support of the neuroprotection of emodin. However, this review highlighted the role of emodin as a potent neurotherapeutic agent; therefore, its evidence-based functionality on neurological disorders (NDs).Item Metadata only An insight into the anticancer potentials of lignan arctiin: A comprehensive review of molecular mechanisms(2024-06-30) Chowdhury R.; Bhuia M.S.; Wilairatana P.; Afroz M.; Hasan R.; Ferdous J.; Rakib A.I.; Sheikh S.; Mubarak M.S.; Islam M.T.; Chowdhury R.; Mahidol UniversityNatural products are being developed as possible treatment options due to the rising prevalence of cancer and the harmful side effects of synthetic medications. Arctiin is a naturally occurring lignan found in numerous plants and exhibits different pharmacological activities, along with cancer. To elucidate the anticancer properties and underlying mechanisms of action, a comprehensive search of various electronic databases was conducted using appropriate keywords to identify relevant publications. The findings suggest that arctiin exhibits anticancer properties against tumor formation and various cancers such as cervical, myeloma, prostate, endothelial, gastric, and colon cancers in several preclinical pharmacological investigations. This naturally occurring compound exerts its anticancer effect through different cellular mechanisms, including mitochondrial dysfunction, cell cycle at different phases (G2/M), inhibition of cell proliferation, apoptotic cell death, and cytotoxic effects, as well as inhibition of migration and invasion of various malignant cells. Moreover, the study also revealed that, among the various cellular pathways, arctiin was shown to be more potent in terms of the PI3K/AKT and JAK/STAT signaling pathways. However, pharmacokinetic investigation indicated the compound's poor oral bioavailability. Because of these findings, arctiin might be considered a promising chemotherapeutic drug candidate.
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