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Publication Open Access Aedesin: structure and antimicrobial activity against multidrug resistant bacterial strains.(2014-08-27) Godreuil, Sylvain; Leban, Nadia; Padilla, Andre´; Hamel, Rodolphe; Natthanej Luplertlop; นัฏฐเนศวร์ ลับเลิศลบ; Chauffour, Aure´ lie; Vittecoq, Marion; Hoh, Franc¸ois; Thomas, Fre´de´ ric; Sougakoff, Wladimir; Lionne, Corinne; Yssel, Hans; Misse, Dorothe´e; Misse, Dorothe´e; Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology.Multidrug resistance, which is acquired by both Gram-positive and Gram-negative bacteria, causes infections that are associated with significant morbidity and mortality in many clinical settings around the world. Because of the rapidly increasing... effects against a large panel of multidrug resistant bacterial strains, directly isolated from infected patients. Based the results from nuclear magnetic resonance spectroscopy analysis, Aedesin has a helix-bend-helix structure typical for a memberPublication Open Access CD2068 potentially mediates multidrug efflux in Clostridium difficile(2017) Chawalit Ngernsombat; Suthasinee Sreesai; Phurt Harnvoravongchai; Surang Chankhamhaengdecha; Tavan Janvilisri; Mahidol University. Faculty of Science. Department of Biochemistry; Mahidol University. Faculty of Science. Department of BiologyClostridium difficile is a major cause of antibiotic-associated diarrhea and the treatment thereof becomes more difficult owing to a rise of multidrug resistant strains. ATP-binding cassette (ABC) transporters are known to play a crucial role... in the resistance to multiple antibiotics. In this study, the potential contribution of an ABC transporter in C. difficile multidrug resistance was investigated. The expression level of the cd2068 gene in C. difficile encoding an ABC transporter was up-regulatedPublication Open Access Prevalence and genotypic relatedness of carbapenem resistance among multidrug-resistant P. aeruginosa in tertiary hospitals across Thailand(2012) Piyatip Khuntayaporn; Preecha Montakantikul; Piroon Mootsikapun; Visanu Thamlikitkul; Mullika Traidej Chomnawang; Mahidol University. Faculty of Pharmacy. Department of Microbiology; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Khon Kaen University. Faculty of Medicine. Department of Medicine; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of MedicineBackground: Increased infection caused by multidrug resistant (MDR) Pseudomonas aeruginosa has raised awareness of the resistance situation worldwide. Carbapenem resistance among MDR (CR-MDR) P. aeruginosa has become a serious life-threatening... that the meropenem resistance rate was the highest reaching over 50% in every hospitals. Additionally, the type of hospitals was a major factor affecting the resistance rate, as demonstrated by significantly higher CR-MDR rates among university and regionalPublication Open Access Measuring ex vivo drug susceptibility in Plasmodium vivax isolates from Cambodia(2017) Suwanna Chaorattanakawee; Chanthap Lon; Soklyda Chann; Kheang Heng Thay; Nareth Kong; You, Yom; Siratchana Sundrakes; Chatchadaporn Thamnurak; Sorayut Chattrakarn; Chantida Praditpol; Kritsanai Yingyuen; Wojnarsk, Mariusz i; Huy, Rekol; Spring, Michele D.; Walsh, Douglas S.; Patel, Jaymin C.; Lin, Jessica; Juliano, Jonathan J.; Lanteri, Charlotte A.; Saunders, David L.; Mahidol University. Faculty of Public HealthBackground: While intensive Plasmodium falciparum multidrug resistance surveillance continues in Cambodia, relatively little is known about Plasmodium vivax drug resistance in Cambodia or elsewhere. To investigate P. vivax antimalarial... dehydrogenase (pLDH) ELISA. P. vivax multidrug resistance gene 1 (pvmdr1) mutations, and copy number were analysed in a subset of isolates. Results: Ex vivo testing was interpretable in 80% of isolates using the pLDH-ELISA, but only 25% with the SMTPublication Open Access Classification of P-glycoprotein-interacting compounds using machine-learning methods(2015-07) Watshara Shoombuatong; Apilak Worachartcheewan; Veda Prachayasittikul; Chanin Nantasenamat; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical InformaticsP-glycoprotein (Pgp) is a drug transporter that plays important roles in multidrug resistance and drug pharmacokinetics. The inhibition of Pgp has become a notable strategy for combating multidrug-resistant cancers and improving therapeutic outcomesPublication Open Access P-Glycoprotein transporter in drug development(2016-02-12) Veda Prachayasittikul; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied TechnologyPublication Open Access Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape.(2014-06-10) Croucher, Nicholas J.; Chewapreecha, Claire; Hanage, William P.; Harris, Simon R.; McGee, Lesley; Linde, Mark van der; Song, Jae-Hoon; Ko, Kwan Soo; Lencastre, Herminia de; Turner, Claudia; Yang, Fan; Sa´ -Lea˜o, Raquel; Beall, Bernard; Klugman, Keith P.; Parkhill, Julian; Turner, Paul; Bentley, Stephen D.; Bentley, Stephen D.; Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit.The multidrug-resistant Streptococcus pneumoniae Taiwan(19F)-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, "vaccine escape" PMEN14 isolates... that originated in the late 1980s in parallel with the acquisition of multiple resistances by close relatives. One of the four detected serotype switches to 19A generated representatives of the sequence type (ST) 320 isolates that have been highly successfulPublication Open Access Drug resistance and IS6110-RFLP patterns of Mycobacterium tuberculosis in patients with recurrent tuberculosis in northern Thailand.(2013-01) Supaporn Sukkasem; สุภาพร สุขเกษม; Yanai, Hideki; Surakameth Mahasirimongkol; Yamada, Norio; Dhanida Rienthong; Prasit Palittapongarnpim; ประสิทธิ์ ผลิตผลการพิมพ์; Srisin Khusmith; ศรีสิน คูสมิทธิ์; Srisin Khusmith; Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology; Mahidol University. Faculty of Science. Department of Microbiologyisolated from patients with relapsed or retreatment pulmonary TB in Chiang Rai province in northern Thailand. Significant differences in multidrug resistance (MDR) (P = 0.025) and resistance to isoniazid (P = 0.025) and rifampin (P = 0.046) between first...The emergence of drug resistant Mycobacterium tuberculosis has become a global threat to tuberculosis (TB) prevention and control efforts. This study aimed to determine the drug resistance profiles and DNA fingerprints of M. tuberculosis strainsPublication Open Access Perspectives on antimicrobial resistance in livestock and livestock products in ASEAN countries(2014) Amornthep Archawakulathep; Thi Kim, Chung Ta; Meunsene, Dethaloun; DidikHandijatno; Hassim, HaslizaAbu; Rovira, Hope R. G.; Myint, Khin Sandar; Baldrias, Loinda R.; Sothy, Meas; Aung, Min; Wahyu, Nenny H.; Chea, Rortana; Sookruetai Boonmasawai; Vannamahaxay, Soulasack; Sunpetch Angkititrakul; Collantes, Therese M. A.; Van, Tho Nguyen; Veerasak Punyapornwithaya; ZunitaZakaria; Rungtip Chuanchuen; Mahidol University. Faculty of Veterinary Sciencetrade. The tendency of bacterial pathogens to become multidrug resistant (MDR) is the most serious concern in AMR. The ASEAN Economic Community (AEC) will be fully established in 2015 and ASEAN cooperation has acknowledged the significance of food safety...Antimicrobial resistance (AMR) in bacteria, particularly in foodborne pathogens, has increasingly become apparent in most parts of the world including ASEAN countries, creating great impact on economy, human and animal health and international foodPublication Open Access Epidemiology of bacteremia caused by uncommon non-fermentative gram-negative bacteria(2013) Pinyo Rattanaumpawan; Prapassorn Ussavasodhi; Pattarachai Kiratisin; Nalinee Aswapokee; Mahidol University. Faculty of Medicine Siriraj Hospital. Division of Infectious Diseases and Tropical MedicineBackground: Prevalence of bacteremia caused by non-fermentative gram-negative bacteria (NFGNB) has been increasing over the past decade. Although many studies have already investigated epidemiology of NFGNB bacteremia, most focused only on common NFGNB including Pseudomonas aeruginosa (PA) and Acinetobacter baumannii (AB). Knowledge of uncommon NFGNB bacteremia is very limited. Our study aimed to investigate epidemiology and identify factors associated with uncommon NFGNB bacteremia. Methods: This observational study was conducted at a university hospital in Thailand during July 1, 2007-Dec 31, 2008. All patients who had at least one blood culture positive for NFGNB and met the criteria for systemic inflammatory response syndrome within 24 hours before/after obtaining the blood culture were enrolled. The NFGNB isolates that could not be satisfactorily identified by the standard biochemical assays were further characterized by molecular sequencing methods. To identify factors associated with uncommon NFGNB bacteremia, characteristics of patients in the uncommon NFGNB group were subsequently compared to patients in the common NFGNB group (AB and PA bacteremia). Results: Our study detected 223 clinical isolates of NFGNB in 221 unique patients. The major causative pathogens were AB (32.7%), followed by PA (27.8%), Stenotrophomonas maltophilia (5.4%), Acinetobacter lwoffii (4.9%) and Burkholderia pseudomallei (2.7%). Infection-related mortality was 63.0% in the AB group, 40.3% in the PA group and 17.4% in the uncommon NFGNB group. Factors associated with uncommon NFGNB bacteremia (OR [95% CI]; p-value) were male sex (0.28 [0.14-0.53]; p < 0.001), hospital-acquired infection (0.23 [0.11-0.51]; p < 0.001), recent aminoglycosides exposure 0.23 [0.06-0.8]; p = 0.01), primary bacteremia (6.43 [2.89-14.2]; p < 0.001]), catheter related infection (4.48 [1.54-13.06]; p < 0.001) and recent vancomycin exposure (3.88 [1.35-11.1]; p = 0.02). Conclusions: Our distribution of causative pathogens was slightly different from other studies. The common NFGNB group had a remarkably higher ID-mortality than the uncommon NFGNB group. Knowledge of factors associated with uncommon NFGNB bacteremia would help physicians to distinguish between low vs. high risk patients.